Reduced Morphine Consumption Using Low Dose Ketamine

Comparison of analgesic effects of morphine with the standard dose of 0.1mg / kg and morphine at a dose of 0.05mg / kg with ketamine at a dose of 0.3mg / kg in patients with multiple trauma

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180129038549N3

Enrollment

Registered

2018-03-05

Start date

2017-10-23

Completion date

Unknown

Last updated

2018-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain in Multiple Trauma Patients. Unspecified multiple injuries

Interventions

Intervention 1: Intervention group:morphine 0.05mg / kg and ketamine IV 0.3 mg / kg. Intervention 2: Control group: Morphine 0.1 mg / kg and placebo 5 cc IV.

Eligibility

Sex/Gender

All

Age

16 Years to 50 Years

Inclusion criteria

Inclusion criteria: Multiple trauma patients Alert Stable vital signs

Exclusion criteria

Exclusion criteria: Psychosis cardiovascular disease open globe injuries severe head trauma RR<60/min

Design outcomes

Secondary

Measure	Time frame
Blood pressure. Timepoint: Before injection, 10, 20 and 30 minutes later. Method of measurement: Manometer( pressure gauge).;Heart rate. Timepoint: Before injection, 10, 20 and 30 minutes later. Method of measurement: Count.;Respiratory rate. Timepoint: Before injection, 10, 20 and 30 minutes later. Method of measurement: Count.;Oxygen saturation level. Timepoint: Before injection, 10, 20 and 30 minutes later. Method of measurement: Pulse oximetry.;Patient Satisfaction. Timepoint: 30 minutes after injection. Method of measurement: 4-level Likert table.	—

Measure

Time frame

Blood pressure. Timepoint: Before injection, 10, 20 and 30 minutes later. Method of measurement: Manometer( pressure gauge).;Heart rate. Timepoint: Before injection, 10, 20 and 30 minutes later. Method of measurement: Count.;Respiratory rate. Timepoint: Before injection, 10, 20 and 30 minutes later. Method of measurement: Count.;Oxygen saturation level. Timepoint: Before injection, 10, 20 and 30 minutes later. Method of measurement: Pulse oximetry.;Patient Satisfaction. Timepoint: 30 minutes after injection. Method of measurement: 4-level Likert table.

—

Primary

Measure	Time frame
Pain score. Timepoint: The times are zero (moment of injection) and 10, 20 and 30 minutes. Method of measurement: Visual Analogue Scale(0-10).;Side effects. Timepoint: 10, 20 and 30 minutes after injection. Method of measurement: Count the number of items registered in the checklist.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarhad Heydari

Esfahan University of Medical Sciences

drfarhadheydari@gmail.com+98 31 3776 9818

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026