Evaluation of the effect of lidocaine-ibuprofen cream in reducing local pain

Effectiveness of topical lidocaine-prilocaine cream in comparison with lidocaine-ibuprofen combination cream in reduction of pain during central venous catheterization

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180129038549N10

Enrollment

100

Registered

2021-05-12

Start date

2021-05-16

Completion date

Unknown

Last updated

2021-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Procedural pain. Acute pain, not elsewhere classified

Interventions

Intervention 1: Intervention group: Patients are treated with Xyla-P cream. A 5% Xyla-P cream is a combination of 2.5% lidocaine and 2.5% perlocaine produced by Iranian chemistry company Iran. For eac

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: All adult patients referred to the emergency department of al-Zahra and Kashani hospitals Need for Central Venous Catheter Insertion Alert Stable vital signs

Exclusion criteria

Exclusion criteria: Visual, mental, or verbal disorders History of favism, methemoglobin, renal and liver disease Skin diseases at or around the CVC insertion site History of drug addiction History of analgesic use within 24 hours before the procedur

Design outcomes

Primary

Measure	Time frame
The severity of pain. Timepoint: After central venous catheter (CVC) insertion. Method of measurement: Visual Analogue Scale.	—

Secondary

Measure	Time frame
Drug side effects such as redness, whitening and skin blemishes. Timepoint: Until the time of discharge. Method of measurement: Standard questionnaire form.;The severity of pain. Timepoint: After lidocaine injection. Method of measurement: Visual Analogue Scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarhad Heydari

Esfahan University of Medical Sciences

drfarhadheydari@gmail.com+98 31 3776 9818

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026