Moderate Hemophilia A. Hereditary factor VIII deficiency
Conditions
Interventions
Intervention 1: Intervention group 1: Resistanve exercise: Resistance training group require to perform six weeks trunk, upper and lower limb exercises (65-75% 1RM) , 40 min per session , three days p
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
Male
Age
35 Years to 55 Years
Inclusion criteria
Inclusion criteria: Men with moderate haemophilia A (factor VIII 1% -5 %) Aged 35–55 years; Body mass index 25–30 kg/m2; No history of an inhibitor; Total Hemophilia Joint Health Score (HJHS) =10 Factor VIII prophylaxis before and during treatment protocol
Exclusion criteria
Exclusion criteria: Clinical signs of active bleeding Participation in regular physical training activities (more than two times per week) in the previous six months High blood pressure at rest (systolic >160 mmHg, diastolic >10 mmHg)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| IL-6: Inflammatory marker. Timepoint: Before and after six weeks exercise. Method of measurement: ELISA kit, Invitrogen, San Diego,USA.;TNF: Inflammatory marker. Timepoint: Before and after six weeks exercise. Method of measurement: ELISA kit, Invitrogen, San Diego,USA.;Hs-CRP:Inflammatory marker. Timepoint: Before and after six weeks exercise. Method of measurement: ELISA kit, Invitrogen, San Diego,USA.;IL-10: Anti inflammatiry marker. Timepoint: Before and after six weeks exercise. Method of measurement: ELISA kit, Invitrogen, San Diego,USA.;Adiponectine: Anti inflammatiry marker. Timepoint: Before and after six weeks exercise. Method of measurement: ELISA kit, Invitrogen, San Diego,USA.;Muscle Thickness and pennation angle. Timepoint: Before and after six weeks exercise. Method of measurement: Ultrasonography, B mode.;Muscle cross sectional area. Timepoint: Before and after six weeks exercise. Method of measurement: Axial plane scans using MRI scanner.;Angular displacement and velocity of the knee and hip joints in three planes including sagital, frontal and transverse planes. Timepoint: Before and after six weeks exercise. Method of measurement: Marking the knee and hip joints and recording by the camera of the motion analysis (Vicon).;Mean, standard deviation, total displacement and velocity of center of pressure during walking and sit to stand in the frontal and sagital planes. Timepoint: Before and after six weeks exercise. Method of measurement: Force plate (Kistler) With a sampling rate of 100 Hz. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactBehnoosh Vasaghi Gharamaleki
Iran University of Medical Sciences
Outcome results
None listed