Dyslipidemia. Disorder of lipoprotein metabolism, unspecified
Conditions
Interventions
Intervention 1: Intervention group: Synbiotic supplement contains 6 probiotic microorganisms: 5 species of Lactobacillus acidophilus, Lactobacillus fermentum, Lactobacillus plantarum, Bifidobacterium
Maltodextrin powder Sachet
2 times a day (one hour before lunch and dinner, dissolved in a glass of water) for 12 weeks.
Sponsors
Ahvaz University of Medical Sciences
Eligibility
Sex/Gender
Male
Age
25 Years to 60 Years
Inclusion criteria
Inclusion criteria: Willingness to cooperate within the project Having dyslipidemia (imbalance of blood lipids or serum lipoproteins include cholesterol or low-density lipoprotein cholesterol (LDL-C) or triglycerides or high-density lipoprotein (HDL)) Having triglyceride in the range of 200-400 mg/dl and LDL-C in the range of 130-190 mg/dl Adult men with aged 25 to 60 years old
Exclusion criteria
Exclusion criteria: Unwillingness to cooperate within the project Shift working Frequent missions or trips outside the province Using chemical or herbal lipid-lowering drugs Familial dyslipidemia Having chronic diseases such as Coronary heart disease, Chronic kidney disease , Cirrhosis Cancers , Endocrine disease (e.g. diabetes, goiters) , some gastrointestinal disease ,malignancies autoimmunity, allergies Adherence to a special diet Significant weight loss or weight gain in the last 6 months Taking dietary supplements of antioxidants, probiotics, prebiotics, synbiotics in the last 6 months Smoking and alcohol and drug abuse
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total Cholestrol. Timepoint: Before and after study. Method of measurement: Spectrophotometry.;Low density lipoprotein. Timepoint: Before and after study. Method of measurement: Spectrophotometry.;Triglyceride. Timepoint: Before and after study. Method of measurement: Spectrophotometry.;High density lipoprotein. Timepoint: Before and after study. Method of measurement: Spectrophotometry. | — |
Secondary
| Measure | Time frame |
|---|---|
| Micro RiboNucleic Acid 27-A. Timepoint: Before and after study. Method of measurement: Real-time Polymerase Chain Reaction.;Micro RiboNucleic Acid 33-A. Timepoint: Before and after study. Method of measurement: Real-time Polymerase Chain Reaction.;Gut microbiota composition. Timepoint: Before and after study. Method of measurement: Real-time Polymerase Chain Reaction.;Endotoxin. Timepoint: Before and after study. Method of measurement: Enzyme-Linked ImmunoSorbent Assay.;Trimethylamin N-oxide. Timepoint: Before and after study. Method of measurement: Spectrophotometry.;Small dense Low Density Lipoprotein. Timepoint: Before and after study. Method of measurement: Enzyme-Linked ImmunoSorbent Assay.;Apo Lipoprotein A-1. Timepoint: Before and after study. Method of measurement: Enzyme-Linked ImmunoSorbent Assay.;Apo Lipoprotein B. Timepoint: Before and after study. Method of measurement: Enzyme-linked ImmunoSorbent Assay.;Short Chain Fatty Acids. Timepoint: Before and after study. Method of measurement: Gas Chromatography.;Interleukin10. Timepoint: Before and after study. Method of measurement: Enzyme-linked ImmunoSorbent Assay. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAnahita Mansoori
Ahvaz University of Medical Sciences
Outcome results
None listed