effectiveness of prolotherapy in reduce pain and functional improvements of osteoarthritis patients

Comparative effectiveness of prolotherapy with hypertonic saline versus ozone and hypertonic saline combination in reduce pain and functional improvements of osteoarthritis patients

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180127038527N1

Enrollment

Registered

2018-02-19

Start date

2017-11-22

Completion date

Unknown

Last updated

2018-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis of knee. Osteoarthritis of knee

Interventions

Intervention 1: Intervention group: Intra-articular injection of 4 ml saline 5% plus 4 ml of lidocaine 2% in the knee With the injection of 7 ml of Ozone at a concentration of 20 µg / ml with lifesty

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Grades 1 or 2 osteoarthritis base on Kellgren- Lawrence radiographic Criterion Osteoarthritis pain for more than three month

Exclusion criteria

Exclusion criteria: Any type of intra-articular injection or prolothrapy in the one past year Knee surgery Grades 3 or 4osteoarthritis base on Kellgren- Lawrence radiographic Criterion

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: Before and after the intervention in weeks 2 and 4 after the last injection. Method of measurement: visual analog scale.;Function. Timepoint: Before and after the intervention in weeks 2 and 4 after the last injection. Method of measurement: oxford knee scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSaeeid Hosseini

Shiraz University of Medical Sciences

hsni.saeeid@gmail.com+98 71 3228 7904

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026