Condition 1: IgE-mediated sensitization to Egg white. Condition 2: IgE-mediated sensitization to Egg white. Anaphylactic reaction due to food Other adverse food reactions, not elsewhere classified
Conditions
Interventions
Intervention group: Three phase including an initial dose escalation during 5 days of hospitalization, to continue the use of received dose at home, to increase the dose up to achieve maintenance dos
Sponsors
Iran University of Medical Sciences
Telavang Company
Dr. Vahid Ghobadi Dana
Eligibility
Sex/Gender
All
Age
4 Years to No maximum
Inclusion criteria
Inclusion criteria: The patients referring to Department of Asthma and Allergy in Rasool Akram Hospital and Jahad Clinic with a history of allergic reaction to egg white up to 2 hours after ingestion and positive Skin Prick test to Egg white The inability to pass the Oral Food Challenge (OFC) according to the protocol of Middelton Book with using pasteurized raw egg white (Produced by Telavang Egg Industries Co.)
Exclusion criteria
Exclusion criteria: Age less than 4 years old History of Cardiovascular diseases Use of Beta-Blockers and ACE Severe and Uncontrolled Asthma
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Desensitization. Timepoint: 6 months. Method of measurement: Pass the Oral food challenge test after 6 months use of egg white.;Specific IgE concentration to Egg white. Timepoint: 6 months. Method of measurement: Immunocap.;Specific IgG4 concentration to Egg white. Timepoint: 6 months. Method of measurement: ImmunoCAP.;The size of Skin Prick Test. Timepoint: 6 months. Method of measurement: The size of wheal and Flare(mm). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Vahid Ghobadi Dana
Iran University of Medical Sciences
Outcome results
None listed