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Effect of Donepezil and Memantine on improving cognitive function

Comparison of the effect of Donepezil and Memantine on improving cognitive function in patients with temporal lobe epilepsy

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20180113038344N1
Enrollment
70
Registered
2018-03-18
Start date
2018-03-21
Completion date
Unknown
Last updated
2018-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Temporal lobe epilepsy. Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures

Interventions

Intervention 1: Intervention group: In this group 10 mg Donepezil is prescribed daily for 16 weeks that is produced by Jalinous Pharmacological Company. Intervention 2: Intervention group: In this gro

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 55 Years

Inclusion criteria

Inclusion criteria: Having age between 18-55 years Having temporal lobe epilepsy Have no other neurological disease Use no medications for treating cognitive disorders willingness to participate in this study

Exclusion criteria

Exclusion criteria: Having mental retardation Having progressive neurological disease Having sensitivity to Memantine or Donepezil

Design outcomes

Primary

MeasureTime frame
The score of Montreal Cognitive Assessment test. Timepoint: Before and immediately after intervention. Method of measurement: Montreal Cognitive Assessment questionnaire.

Secondary

MeasureTime frame
Incidence of sensitivity to Memantine. Timepoint: During intervention. Method of measurement: observation.;Incidence of sensitivity to Donepezil. Timepoint: During intervention. Method of measurement: observation.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMarjan Oustad

Esfahan University of Medical Sciences

oustadmarjan@yahoo.com+98 31 3668 0048

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026