Effect of prime ultrafiltration on pro-calcitonin and respiratory function in the infants undergoing cardiopulmonary bypass

Effect of zero-balanced ultrafiltration of priming blood on pro-calcitonin and respiratory function in the infants undergoing cardiopulmonary bypass

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180110038301N1

Enrollment

Registered

2018-05-21

Start date

2017-09-06

Completion date

Unknown

Last updated

2018-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

infants required cardiac surgery with cardiopulmonary bypass pump (due to congenital anomalies). Other congenital malformations of heart

Interventions

Intervention 1: Intervention group: standard ultrafiltration AND zero-balanced ultrafiltration on the prime solution during cardiopulmonary bypass pump (CPB). Intervention 2: Control group: standard u

Eligibility

Sex/Gender

All

Age

No minimum to 18 Months

Inclusion criteria

Inclusion criteria: pregnancy duration equal or more than 37 weeks Parental consent weight under 10 kg open heart surgery no other major congenital anomaly affected post-op recovery No previous sternotomy

Exclusion criteria

Exclusion criteria: cardiac arrest during the operation using defibrillator during the operation aortic clamp time less than 30 minutes

Design outcomes

Primary

Measure	Time frame
Mean level of serum procalcitonin. Timepoint: first and 24 hour after admission to ICU. Method of measurement: Electro-chemiluminescence immunoassay (ECLIA) method via cobas, Roshe.;Respiratory Index. Timepoint: pre-operative after induction of anesthesia, at the end of operation and 2 hours after ICU admission. Method of measurement: Ventilator output.;Pulmonary compliance. Timepoint: pre-operative after induction of anesthesia, at the end of operation and 2 hours after ICU admission. Method of measurement: Ventilator output.	—

Measure

Time frame

Mean level of serum procalcitonin. Timepoint: first and 24 hour after admission to ICU. Method of measurement: Electro-chemiluminescence immunoassay (ECLIA) method via cobas, Roshe.;Respiratory Index. Timepoint: pre-operative after induction of anesthesia, at the end of operation and 2 hours after ICU admission. Method of measurement: Ventilator output.;Pulmonary compliance. Timepoint: pre-operative after induction of anesthesia, at the end of operation and 2 hours after ICU admission. Method of measurement: Ventilator output.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSana Niknam

Rajaie Cardiovascular Medical and Research Center

sananiknam@rhc.ac.ir+98 21 23921

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026