Effect of vitamin C infusion on aldosterone and renin levels and erythrocyte sedimentation rate

Effect of vitamin C infusion on aldosterone and renin levels and erythrocyte sedimentation rate in patients under anesthesia with etomidate in elective laparotomy

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180107038251N5

Enrollment

102

Registered

2022-01-15

Start date

2022-02-05

Completion date

Unknown

Last updated

2022-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

adrenal glands Suppression. Disorder of adrenal gland, unspecified

Interventions

Intervention 1: Intervention group: Initially, patients are pre-oxygenated with 100% oxygen and a flow rate of 5 liters per minute for 3 to 5 minutes. Anesthesia is performed in the same way in all pa

Eligibility

Sex/Gender

All

Age

25 Years to 70 Years

Inclusion criteria

Inclusion criteria: Patients aged 25-70 years Patients with American Society of Anesthesiologists (ASA) class 1 and 2 Patients candidate for elective laparotomy surgery

Exclusion criteria

Exclusion criteria: Patients with severe debilitating disease Patients with blood disorders Renal and hepatic impairment, diabetes, severe septic shock or sepsis, Addison or Cushing's disease, epilepsy Alcohol abuse smokers Pregnant women trauma Severe allergy to any of the drugs used Patients with a history of corticosteroid use with a dose that can suppress the pituitary-adrenal cortisol axis Severe hemodynamic changes during surgery Duration of surgery more than 4 hours The patient's unwillingness to participate in the study

Design outcomes

Primary

Measure	Time frame
Aldosterone. Timepoint: Before induction of anesthesia and 4 hours after anesthesia. Method of measurement: Laboratory.;Renin. Timepoint: Before induction of anesthesia and 4 hours after anesthesia. Method of measurement: Laboratory.;ESR (Erythrocyte Sedimentation Rate). Timepoint: Before induction of anesthesia and 4 hours after anesthesia. Method of measurement: Laboratory.	—

Secondary

Measure	Time frame
Oxygen saturation. Timepoint: Before surgery and every 2 hours after anesthesia. Method of measurement: Monitoring.;Heart rate. Timepoint: Before surgery and every 2 hours after anesthesia. Method of measurement: Monitoring.;Blood pressure. Timepoint: Before surgery and every 2 hours after anesthesia. Method of measurement: Monitoring.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNazanin Amini

Arak University of Medical Sciences

nazaninamini69@yahoo.com+98 86 3417 3507

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026