Radiotherapy-induced oral mucositis. Oral mucositis (ulcerative) due to radiation
Conditions
Interventions
Intervention 1: Control group: Receiving routine treatment (Acetaminophen 500 mg three times a day, Made by Jalinous company) + placebo mouthwash containing distilled water and glycerin twice a day ma
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Patients treated for head and neck cancer with chemo-radiotherapy Age between 18 and 70 years Absence of serious dental problems Absence of impacted teeth No cusp or sharp filling Total radiation is between 50 and 70 Gy during treatment Exposure of at least half of the oral cavity to radiation Patients should take one of the drugs cisplatin or 5-fluorouracil in their chemotherapy regimen.
Exclusion criteria
Exclusion criteria: Severe infections that require antibiotics. Patients who have been allergic to any of the herbal extracts or previous radiotherapy Inability of the patient to implement the treatment protocol Renal failure (eGFR <50 ml / min) Liver failure (serum level 2 to 3 times higher than normal)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in mucositis score based on World Health Organization scoring. Timepoint: Every week from the beginning of the drug (week zero) to the end of the study (week seven). Method of measurement: World Health Organization mucositis scoring questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Vahid Reza Askari
Mashhad University of Medical Sciences
Outcome results
None listed