Comparison of Intraperitoneal of Magnesium Sulphate and Dexmedetomidine for Postoperative pain

Comparison of Intraperitoneal of Magnesium Sulphate and Dexmedetomidine for Postoperative Analgesia after Laparoscopic Cholecystectomy

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20180103038196N9

Enrollment

Registered

2025-12-08

Start date

2025-12-19

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Symptomatic gallstones. Calculus of gallbladder with acute cholecystitis without obstruction

Interventions

Intervention 1: Intervention group 1: Intraperitoneal injection of 30 ml of bupivacaine 0.25% + 50 mg/kg magnesium sulfate. Intervention 2: Intervention group 2: Intraperitoneal injection of 30 ml of

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Patients between 18 and 60 years old ASA class I and II Candidates for laparoscopic cholecystectomy

Exclusion criteria

Exclusion criteria: Allergy to the drugs used in the study Chronic alcoholism Systemic diseases such as severe heart disease, lung disease, and diabetes mellitus Renal dysfunction

Design outcomes

Primary

Measure	Time frame
Postoperative pain. Timepoint: Upon entering the recovery room, 2, 4, 6, 8, 10, 12, and 24 hours after surgery. Method of measurement: Using the Visual Analogue Scale criteria.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAlireza olapour

Ahvaz University of Medical Sciences

alirezaolapour29@gmail.com+98 61 2222 9223

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 7, 2026