Acute Mania. Bipolar disorder, current episode manic without psychotic features
Conditions
Interventions
Intervention 1: Intervention group: patients receiving folic acid + sodium valproate .Sodium valproate starts at 400 mg per day and will increase up to maximum of 20 mg per kg per day or the highest
Sponsors
Gorgan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Being at the age of 18 to 50 years Diagnosis of type 1 bipolar disorder, being in mania episode based on diagnostic criteria DSM-5 (By a semi-structured interview by a psychiatrist and diagnosis based on minimum score 20 from the Young Mania Rating Scale)
Exclusion criteria
Exclusion criteria: Intolerance to increase the dose of the drug over a specified period of time. Presence of anemia Abnormal folic acid levels Changing the diagnosis and rejection of the initial diagnosis during the course of treatment History of ADHD psychiatric diagnosis combined with medication and other diseases history of admission to the psychiatric hospital during the past three months, Positive pregnancy test in women receive other medications, such as anti-mania treatments, two weeks prior to study or during the study history of sodium valproate sensitivity
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement of acute mania based on the results of the used tests. Timepoint: The beginning of the study (before the intervention) and 3 and 6 weeks after the intervention. Method of measurement: Young Mania Rating Scale and Mini-Mental State Examination 1. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public Contact??Dr Peyman Rad
Gorgan University of Medical Sciences
Outcome results
None listed