Tuberculosis. Respiratory tuberculosis
Conditions
Interventions
Intervention 1: Intervention group: All patients receive standard dose (by weight) treatment with first-line drugs (isoniazid, rifampin and pyrazinamide).In addition, for the intervention group, Liver
Sponsors
Esfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 65 Years
Inclusion criteria
Inclusion criteria: Age range 20 to 65 Active pulmonary or extrapulmonary tuberculosis No first-line anti-tuberculosis drugs (isoniazid, rifampin, pyrazinamide) in all patients in the past 8 weeks and starting on treatment No known hepatotoxic drugs (sodium valproate, methotrexate and sulfonamides) No continuous use of acetaminophen No systemic glucocorticoids, supplements containing thistle, dandelion, barberry, turmeric or artichoke in the past 4 weeks
Exclusion criteria
Exclusion criteria: Patient dissatisfaction alcohol consumption liver disease Discontinue medication for any reason other than liver toxicity Patient Withdrawal from Study Continuation Not taking the study tablet for at least 3 consecutive days
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hepatic Enzymes (AST, ALT, ALP). Timepoint: Before and one week and two weeks after intervention. Method of measurement: blood test.;Bilirubin (Direct and Total). Timepoint: Before and one week and two weeks after intervention. Method of measurement: blood test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad Reza Yazdani
Esfahan University of Medical Sciences
Outcome results
None listed