Investigation effect of oral paracetamol in closing PDA in premature neonates

Investigation effect of oral acetaminophen and ibuprofen on Patent Ductus Arteriosus in preterm neonates

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20171227038102N1

Enrollment

Registered

2018-07-03

Start date

2014-10-23

Completion date

Unknown

Last updated

2018-09-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patent Ductus Arteriosus. Patent ductus arteriosus

Interventions

Intervention 1: Intervention group: Premature infants who received oral acetaminophen 10 mg/kg every six hour for three days. Intervention 2: Control group: Premature infants who received oral ibuprof

Eligibility

Sex/Gender

All

Age

No minimum to 1 Days

Inclusion criteria

Inclusion criteria: preterm neonate Patent Ductus Arteriosus

Exclusion criteria

Exclusion criteria: Congenital heart disease afflicted by PDA Neonates with syndromes Increased pulmonary arterial pressure with left to right shunt Neonates who have digestive intolerance

Design outcomes

Primary

Measure	Time frame
Closure of Patent Ductus Arteriosus. Timepoint: At the beginning of the study. Method of measurement: By echocardiography.	—

Secondary

Measure	Time frame
Side effects. Timepoint: The entire study period. Method of measurement: Serial clinical examinations.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahmoud Samadi

Tabriz University of Medical Sciences

dr.samadi.pediatrics@gmail.com+98 41 3335 7310

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026