Sarcopenia. Sarcopenia
Conditions
Interventions
Intervention 1: Intervention group: receiving 400 grams per day of yogurt fortified with beta-hydroxy beta-butyl butyrate (HMB), vitamin D, and C for 12-week intervention that were produced by Zarrin
Rehabilitation
Placebo
Intervention group: receiving 400 grams per day of yogurt fortified with beta-hydroxy beta-butyl butyrate (HMB), vitamin D, and C for 12-week intervention that were produced by Zarrin Ghazal Industria
Control group: receiving 400 grams per day of placebo yogurt for 12-week intervention that were produced by Zarrin Ghazal Industrial Co. (Daity)
Sponsors
Shiraz University of Medical Sciences
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: Men and women aged 65 years and older Sarcopenia diagnosis according to European Working Group on Sarcopenia in Older People (EWGSOP) guidelines
Exclusion criteria
Exclusion criteria: Subjects unable to move without crutches, walker or other assistive devices. Subjects with artificial limbs. Subjects with history of chronic disease (e.g. Congestive Heart Failure (CHF), Chronic Obstructive Pulmonary Disorder (COPD), Chronic Renal Failure (CRF), cirrhosis liver failure and active cancer). Subjects with history of kidney stones. Subjects who regularly consume any medications interfering with nutritional intervention (e.g. steroids, heparin, free amino acid, antioxidant, omega-3, vitamin D supplements).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fat-free mass. Timepoint: Before and after intervention. Method of measurement: Dual energy X-ray Absorptiometry (DXA); Bioelectrical Impedance Analysis (BIA). | — |
Secondary
| Measure | Time frame |
|---|---|
| Hand grip. Timepoint: Before and after intervention. Method of measurement: Hydraulic Hand Dynamometer.;Physical performance (gait speed). Timepoint: Before and after intervention. Method of measurement: Stopwatch.;Physical activity. Timepoint: Before and after intervention. Method of measurement: International Physical Activity Questionnaire (IPAQ).;Nutritional status. Timepoint: Before and after intervention. Method of measurement: Mini Nutritional Assessment (MNA) questionnaire.;Quality of life. Timepoint: Before and after intervention. Method of measurement: The Short Form Health Survey-12 (SF-12) questionnaire.;25- hydroxy vitamin D (25-OHD) level. Timepoint: Before and after intervention. Method of measurement: Chemiluminescence immunoassay (CLIA) method.;Albumin level. Timepoint: Before and after intervention. Method of measurement: Enzyme-linked immunosorbent assay (ELISA) kit.;Creatinine level. Timepoint: Before and after intervention. Method of measurement: Jaffe’s method.;C-Reactive Protein (hs-CRP) level. Timepoint: Before and after intervention. Method of measurement: Enzyme-linked immunosorbent assay (ELISA) kit.;Insulin-like Growth Factor – 1 (IGF-1). Timepoint: Before and after intervention. Method of measurement: Chemiluminescence immunoassay (CLIA) method.;Fasting Blood Sugar (FBS) level. Timepoint: Before and after intervention. Method of measurement: Auto analyser.;Fasting insulin level. Timepoint: Before and after intervention. Method of measurement: Enzyme-linked immunosorbent assay (ELISA) kit.;Malondialdehyde (MDA) level. Timepoint: Before and after intervention. Method of measurement: Spectrophotometry.;Blood urea nitrogen level. Timepoint: Before and after intervention. Method of measurement: Chemical Method (Diazine).;Lipid profile (LDL, HDL, Triglyceride, total Cholesterol). Timepoint: Before and after intervention. Method of measurement: Chemical Method (Kit). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Mohammad Hossein Dabbaghmanesh
Shiraz University of Medical Sciences
Outcome results
None listed