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Eraddication of Helicobacter pylori for quadruple therapy with base of Clarithromycin compared with Levofloxacin

Comparison of the efficacy of Levofloxacin and Clarithromycin in quadruple therapy for the eradication of Helicobacter pylori

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20171223038001N1
Enrollment
210
Registered
2018-01-05
Start date
2017-12-26
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Helicobacter pylori infection. Helicobacter pylor

Interventions

Intervention group: Patients with Helicobacter Pylori infection receiving four regimens based on levofloxacin 500 mg once daily for 14 days..
Treatment - Drugs
Intervention group: Patients with Helicobacter Pylori infection receiving four regimens based on levofloxacin 500 mg once daily for 14 days.

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Aged 18 years and older Patients with dyspepsia and upper digestive tract symptoms Peptic Ulcers in Upper Gastrointestinal Endoscopy Helicobacter pylori infection in rapid test of urease The desire to participate in the study Lack of severe illness Not having a history of upper gastrointestinal surgery Not taking antibiotics, PPIs and NSAIDs in the last three months Not having eradication history of Helicobacter pylori Absence of ContraIndications for the Consumption of quadruple therapy

Exclusion criteria

Exclusion criteria: Low drug intake (for any reason) Incidence of severe drug complications during the study

Design outcomes

Primary

MeasureTime frame
Eradication of Helicobacter pylori infection. Timepoint: Stool antigen Helicobacter pylori test 4 weeks after discontinuation of treatment. Method of measurement: Stool antigen Helicobacter pylori test.

Secondary

MeasureTime frame
Dyspepsia severity. Timepoint: Before treatment and 4 weeks after treatment. Method of measurement: questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public Contactreyhane hosseini

Esfahan University of Medical Sciences

reyhane_001@yahoo.com+98 31 3230 4933

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026