Studying the effect of probiotics on intestinal colonization of pathogenic bacteria and Candida in very low birth weight premature infants admitted to the neonatal intensive care unit

Studying the effect of probiotics on intestinal colonization of pathogenic bacteria and Candida in very low birth weight premature infants admitted to the neonatal intensive care unit.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20171218037936N4

Enrollment

130

Registered

2025-10-08

Start date

2025-10-23

Completion date

Unknown

Last updated

2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intestinal Colonization by multidrug-resistant organisms and Candida species.. Bacterial intestinal infection, unspecified

Interventions

Intervention 1: Intervention group: The probiotic group, which includes two subgroups of breastfed infants and formula-fed infants, will be assigned. From the start of feeding, five drops of probiotic

Eligibility

Sex/Gender

All

Age

No minimum to 3 Days

Inclusion criteria

Inclusion criteria: Premature, low birth weight (birth weight between 1000 and 1500 grams) Gestational age less than 32 weeks Admission to the neonatal intensive care unit (NICU) within the first 72 hours of life

Exclusion criteria

Exclusion criteria: Dissatisfaction of the patient's parents Infant with digestive disorders after entering the study (intestinal obstruction, severe digestive diseases, etc.) Drug allergy Mortality

Design outcomes

Primary

Measure	Time frame
Rate of intestinal colonization with pathogenic bacteria based on stool culture. Timepoint: Day 6 after the start of the intervention. Method of measurement: Microbiological culture of stool sample.	—

Secondary

Measure	Time frame
Results of the Stool Exam. Timepoint: Day 6 after the start of the intervention. Method of measurement: Direct microscopic examination of the stool sample.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactKamran Dehghan

Oroumia University of Medical Sciences

dehghan.k@umsu.ac.ir+98 44 3365 4154

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026