The effect of ondansetrone and metoclopramide on postoperative nausea and vomiting in Gynecological Laparoscopic Surgery

Comparison of effect of ondansetrone plus dexamethasone and metoclopramide plus dexamethasone on postoperative nausea and vomiting in Gynecological Laparoscopic Surgery

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20171216037910N2

Enrollment

Registered

2019-08-31

Start date

2017-06-10

Completion date

Unknown

Last updated

2019-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post operative nausea and vomiting. Nausea and vomiting

Interventions

Intervention 1: Intervention group: Intravenous administration of 4mg ondansetron plus 8mg dexamethasone. Intervention 2: Intervention group: Intravenous administration of 10mg metoclopramide with 8mg

Eligibility

Sex/Gender

Female

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Fasting for 8 hours before surgery ASA classification 1& 2 No history of co-existing disease: cardiovascular, respiratory, diabetes, gastrointestinal and motion sickness.

Exclusion criteria

Exclusion criteria: History of post operative nausea and vomiting emergency surgery Become an open surgical procedure

Design outcomes

Primary

Measure	Time frame
Post operative nausea and vomiting. Timepoint: ?Emergence of anesthesia (time zero), on arrival to recovery, and at 2, 4, 6, 12 and 24 hours after surgery. Method of measurement: Visual Analogue Scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactKhadijeh Daseh

Sanandaj University of Medical Sciences

fereshtehdaseh@yahoo.com+98 87 3334 2561

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026