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The analgesic effect of Nebulized Morphine, Fentanyl Transdermal Patch and Oral Methadone

The comparison of analgesic effects of nebulized morphine with fentanyl transdermal patch and oral methadone for cancer patients in terminal stages

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20171211037834N1
Enrollment
90
Registered
2018-02-17
Start date
2017-04-21
Completion date
Unknown
Last updated
2018-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Breast cancer. Condition 2: Lung cancer. Condition 3: Prostate cancer. Condition 4: Liver cancer. Condition 5: Colon cancer. Condition 6: Stomach cancer. Condition 7: Uterus cancer. Condition 8: Bladder cancer. Malignant neoplasm of breast Malignant neoplasm of bronchus and lung Malignant neoplasm of prostate Liver cell carcinoma Malignant neoplasm of colon Malignant neoplasm of stomach Malignant neoplasm of uterus, part unspecified Malignant neoplasm of bladder

Interventions

Intervention 1: Intervention group: nebulized group, received nebulization of 20-mg Morphine, repeated every 10minutes with a maximum of 3 nebulizations. Intervention 2: Intervention group: Fentanyl g

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Suffering from moderate or severe pain Patient awareness about his/her situation and illness Suitable Glasgow Coma Scale (GCS) for patient cooperation

Exclusion criteria

Exclusion criteria: Allergy to Opioids Hypotension(Systolic Blood pressure lower than 110 mmHg) Bradypnea (respiration rate less than 12 times per minutes) Hypoxemia (Oxygen saturation lower than 90 percent in room temperature) Rhinitis Liver and kidney disorders Hypothyroidism Prostate hypertrophy Addison's disease

Design outcomes

Primary

MeasureTime frame
Pain. Timepoint: At the beginning of the study (before the intervention) and at the beginning and end of each day for 3 days. Method of measurement: Visual Analog Score that is numbered from 0 to 10.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahdi Ebrahini

Esfahan University of Medical Sciences

m.ebrahimi@resident.mui.ac.ir+98 31 3771 8986

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026