The effect of oral melatonin supplementation on the number and quality of oocytes and embryos in infertile women with endometriosis

The effect of oral melatonin supplementation on the number and quality of oocytes and embryos in infertile women with endometriosis and undergoing intracytoplasmic sperm insemination

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20171209037794N5

Enrollment

100

Registered

2023-10-01

Start date

2023-10-02

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endometriosis. Endometriosis

Interventions

Intervention 1: Intervention group: patients will receive 5 mg melatonin tablet (Jalinous Pharmacetical Company), one hour before sleep, once a day for 2 months. Intervention 2: Control group: patien

Eligibility

Sex/Gender

Female

Age

20 Years to 40 Years

Inclusion criteria

Inclusion criteria: Infertile women 20 to 40 years old under ART treatment along with laparoscopy or ultrasound report indicating the presence of endometriosis

Exclusion criteria

Exclusion criteria: Premature ovarian failure. severe male factor according to the criteria (WHO), sperm count less than 15 million per milliliter and motility less than 50% and normal morphology less than 4%. Occurrence of complications and drug sensitivity such as (fatigue, headache, blurred vision, nausea, diarrhea). Diagnosis of adenomyosis and chronic diseases including thyroid, adrenal diabetes, current malignancy or history of malignancy, uterine myoma and PID . Patients whose infertility is due to obstruction problems, genetic problems or hormonal problems.

Design outcomes

Primary

Measure	Time frame
Number and quality of embryos. Timepoint: 24 hours after ICSI. Method of measurement: Microscopic assay.	—

Secondary

Measure	Time frame
The number and quality of oocytes. Timepoint: oocyte pick up day. Method of measurement: Microscopic Assay.;Fertilization rate. Timepoint: 24 hours after ICSI. Method of measurement: Microscopic Assay.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactParvaneh Mirabi

Babol University of Medical Sciences

parvaneh_mirabi@yahoo.com+98 11 3219 0558

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026