Male infertility. Oligospermia
Conditions
Interventions
Intervention 1: Intervention group: Ceratonia siliqua syrup twice a day for three months. Intervention 2: Control group: 100 mg capsule of vitamin E once a day for three months.
Sponsors
Babol University of Medical Sciences
Babol University of Medical Sciences
Eligibility
Sex/Gender
Male
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 20 - 45 years of age, who had complained of infertility for at least 12 months, and had no history of surgical or medical treatments for infertility Unspecified oligospermia based on WHO criteria (sperm count less than 20 million per ml, type A motility less than 25%, and type B motility less than 50%; normal morphology less than 15%); Having a BMI less than 30 Not smoking, drinking alcohol, and addiction to substance Normal level of gonadotropins, testosterone and Prolactin Lack of systemic diseases, such as diabetes and thyroid, cerebrovascular disease and had no history of chemotherapy
Exclusion criteria
Exclusion criteria: A history of vasectomy or obstructive azoospermia Azospermia and chromosomal abnormalities such as kleinfelter's Syndrome Hypogonadism or pituitary abnormalities The use of antioxidant supplements in the last three months Taking medications that stimulate the sexual system or disrupt the sex hormones Having severe physical activity Genital tract infection, recurrent or residual varicocoele and history of cryptorchidism Infectious diseases characterized by fever and leukocytosis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sperm count. Timepoint: Before and three months after intervention. Method of measurement: Semen analysis.;Sperm morphology. Timepoint: Before intervention and three months after intervention. Method of measurement: Semen analysis.;Sperm motility. Timepoint: Before and three months after intervention. Method of measurement: Semen analysis. | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum concentrations of Malondialdehyde. Timepoint: Before and three months after intervention. Method of measurement: TBARS method using Spectrophotometer.;Sex hormones. Timepoint: Before and three months after intervention. Method of measurement: Eliza.;Superoxide dismutase enzyme. Timepoint: Before and three months after intervention. Method of measurement: Calorimetric.;Zinc. Timepoint: Before and three months after intervention. Method of measurement: Atomic Absorption Spectrophotometry.;Selenium. Timepoint: Before and three months after intervention. Method of measurement: Atomic Absorption Spectrophotometry. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Parvaneh Mirabi
Babol University of Medical Sciences
Outcome results
None listed