Investigating the effect of Inofolic in women with PCOS

Investigating the effect of Inofolic on the expression of genes related to oocyte quality and oxidative stress parameters in follicular fluid and fertility rate in women with PCOS in IVF cycles

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20171208037790N1

Enrollment

Registered

2018-04-28

Start date

2017-12-22

Completion date

Unknown

Last updated

2018-05-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

polycystic ovary syndrome. Polycystic ovarian syndrome

Interventions

Intervention 1: Intervention group: intervention group receiving an antagonist dose (4 grams per day of myoinozitol + folic acid 400 mcg) for 1 month before and 2 weeks after the start of the antagoni

Eligibility

Sex/Gender

Female

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: age between 18 and 40 suffering from polycystic ovary syndrome candidate for IVF treatment

Exclusion criteria

Exclusion criteria: concomitant metabolic disease like diabetes allergy to myoinositol morbid obesity

Design outcomes

Primary

Measure	Time frame
Expression of genes related to oocyte quality in follicular fluid. Timepoint: Measurement is performed immediately after ovulation stimulation and puncture. Method of measurement: Polymerase chain reaction.	—

Secondary

Measure	Time frame
Oxidative stress parameters in follicular fluid. Timepoint: Measurement is performed immediately after ovulation stimulation and puncture. Method of measurement: Reactive Oxygen Species (ROS) Assay Kit & Total Antioxidant Capacity(TAC) Assay Kit.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyedeh Azam Tabatabai Nejad

Iran University of Medical Sciences

tabatabainegad.sa@tak.iums.ac.ir+98 21 6642 4231

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026