The effect of levothyroxine in subclinical hypothyroidism

The effect of levothyroxine in comparison with placebo on serum osteocalcin levels in patients with subclinical hypothyroidism

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20171129037677N1

Enrollment

Registered

2018-04-27

Start date

2017-09-23

Completion date

Unknown

Last updated

2018-05-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Subclinical hypothyroidism. Subclinical iodine-deficiency hypothyroidism

Interventions

Intervention group: Levothyroxine receptor.

Eligibility

Sex/Gender

All

Age

20 Years to 40 Years

Inclusion criteria

Inclusion criteria: People aged 20-40 years old referred to the endocrinology clinic Subclinical hypothyroidism have indications of treatment(Tsh5-15 andT3-T4 in normal range)

Exclusion criteria

Exclusion criteria: History of hypothyroidism Treated with antithyroid drugs Metabolic bone disorder Hypoparathyroid and hyperparathyroid Acromegaly Drugs that cause thyroid dysfunction: Interferon-tyrosine kinase-cortisone and ocp Drugs that affect insulin levels

Design outcomes

Primary

Measure	Time frame
Serum osteocalcin levels. Timepoint: Measurement of osteocalcin levels before the intervention and two months later. Method of measurement: Serum level evaluation.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMasoud Mohebbi

Mashhad University of Medical Sciences

MohebbiM@mums.ac.ir+98 51 3802 2358

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 15, 2026