The Effect of Eight-Week Concurrent Training on Expression of Tumor Suppressor Genes in Men with Prostate Cancer

The Effect of Eight-Week Concurrent Training on Expression of P53 and P21 Tumor Suppressor Genes in Men with Prostate Cancer

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20171128037667N1

Enrollment

Registered

2018-04-28

Start date

2018-03-06

Completion date

Unknown

Last updated

2018-05-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

prostate cancer. Carcinoma in situ of prostate

Interventions

Intervention 1: Intervention group: Experimental group with practice protocol contain a concurrent training course (aerobic-resistance) that designed by the researcher (according to the American Colle

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: Subjects are putted at the stage T1 and T2 of the disease and are treated under the same way. The entering criteria for the study include: Physical health based on a medical history questionnaire that has no history of cardiovascular disease, high blood pressure, diabetes, renal disease, no smoking or participation in any exercise program at least 2 months before take part in Exercise Training program Subjects get allowed to enter the project after a cardiovascular examination, blood pressure measurement and ECG monitoring by a specialist. Take The Physical activities readiness questionnaire (PAR-Q) and The informed consent form for participation in this research by subjects.

Exclusion criteria

Exclusion criteria: Not attending more than 3 sessions having of heart or lung disease Change in health that prevent physical activity

Design outcomes

Primary

Measure	Time frame
P53 tumor suppressor protein. Timepoint: Before the intervention and the end of the intervention. Method of measurement: Blood samples will be collected 24 hours before the training starts and 48 hours after the last exercise session.;P21 tumor suppressor protein. Timepoint: Before the intervention and the end of the intervention. Method of measurement: Blood samples will be collected 24 hours before the training starts and 48 hours after the last exercise session.;Aerobic capacity. Timepoint: Before the intervention and the end of the intervention. Method of measurement: To estimate the maximum oxygen consumption, the Modified Bruce test on the treadmill [based on the maximum oxygen consumption equation: 8.545 + (test run time×2.282)].	—

Measure

Time frame

P53 tumor suppressor protein. Timepoint: Before the intervention and the end of the intervention. Method of measurement: Blood samples will be collected 24 hours before the training starts and 48 hours after the last exercise session.;P21 tumor suppressor protein. Timepoint: Before the intervention and the end of the intervention. Method of measurement: Blood samples will be collected 24 hours before the training starts and 48 hours after the last exercise session.;Aerobic capacity. Timepoint: Before the intervention and the end of the intervention. Method of measurement: To estimate the maximum oxygen consumption, the Modified Bruce test on the treadmill [based on the maximum oxygen consumption equation: 8.545 + (test run time×2.282)].

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Countries

Iran (Islamic Republic of)

Contacts

Public Contactmohammad asghari rekabdarkolaee

Islamic Azad University

asghari.moh@gmail.com+98 11 4253 2765

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026