Iritable bowel syndrom. Irritable bowel syndrome
Conditions
Interventions
Intervention 1: Intervention group 1: First group receive Cumin powder and Mebeverin placebo capsule. Herbal powder in determined ratio consists of Cuminum cyminum L., Trachyspemum ammi (L.) Sprague,
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
16 Years to 65 Years
Inclusion criteria
Inclusion criteria: Age:16-65 years old IBS patients according to ROME 4 criteria, without red flags of organic diseases such as anemia, weight loss, night pin, OB positive, recent changes in bowel habit especially in patient more than 50 years old Moderate to severe symptoms according to IBS severity score (Visual analogue scale score >24-100) Fulfill the consent form Ability to understand and give response exactly Accessible and resident in Tehran Do not have metabolic or endocrine disorders such as untreated hypothyroidism and neurologic diseases, congenital neuromuscular diseases, end organ (kidney and liver) failures, tumors and other organ failures
Exclusion criteria
Exclusion criteria: Acute or chronic mental or psychological disorders such as bipolar disorder, major depression, schizophrenia, dementia and mental retardation Pregnancy and breast feeding History of allergic reaction to Apiaceae family or to any part of the drug History of addiction to alcohol or opiates in recent 6 months History of abdominal surgery (except non complicated appendectomy), C/S, laparoscopic surgery or repair of hernia Use of medication that has effect on bowel movement, long term use of antibiotics, anti diarrhea, laxatives, anticholinergics, opium containing drugs, resins(they could be enrolled after 1 week abstinence if they could stop their medication) Antibiotic consumption in recent month
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in symptoms of irritable bowel syndrome according to IBS-SS questioner (irritable bowel syndrome severity score) that measure abdominal pain severity and frequency and degree of bloating and degree of satisfaction with defecation and degree of disturbance in quality of life. each variable will be measured according "visual analog scale" from 0-100 (in sum will be 0-500). changes in each symptom before and after treatment will be measured.? Equal or more than 50% improvement in IBS-SS will be considered response to treatment. Timepoint: Before intervention and after 1 month treatment. Method of measurement: IBS-SS questioner (irritable bowel syndrome severity score). | — |
Secondary
| Measure | Time frame |
|---|---|
| IBS Quality Of Life score. Timepoint: Before intervention nd 1 month after beginning of treatment. Method of measurement: IBS-QOL questioner that measure changes in quality of life in ptients with irritable bowel syndrome. ( By means of it's Persian translated version that it's validity and reliability has been tested.). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactKhadijeh Hatami
Tehran University of Medical Sciences
Outcome results
None listed