Comparison of the effectiveness of one session and multi-session treatment in individuals with specific phobia

Comparison of the effectiveness of exposure-based one-session with multi-session treatment on psychological symptoms, inflammatory-gene expression, and level of cytokines and hormones, in individuals with specific phobia.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20171123037602N1

Enrollment

Registered

2018-09-30

Start date

2018-11-21

Completion date

Unknown

Last updated

2020-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rat phobia. Animal type phobia

Interventions

Intervention 1: Intervention group: One-session cognitive-behavioral therapy for three hours in accordance with Ost’s manual. Intervention 2: Intervention group: Exposure-based cognitive-behavioral th

Eligibility

Sex/Gender

Female

Age

18 Years to 35 Years

Inclusion criteria

Inclusion criteria: Having Body Mass Index in the range of 18 to 35 kg/m2 Being at Luteal phase Having a specific phobia disorder (mouse and rat) based on DSM-V criteria, using the ADIS-IV structured interview

Exclusion criteria

Exclusion criteria: History of a previous exposure to mice and rats Using anti-anxiety, psychoactive, beta-blocker, hormonal or contraception drugs Smoking cigarette or tobacco Having the history of mental illness, cardiovascular, metabolic or other chronic diseases

Design outcomes

Primary

Measure	Time frame
Fear of the rat based on mice phobia questionnaire. Timepoint: 1- Baseline measurement 2- Pre-treatment measurement after facing with laboratory rat 3- Post-treatment evaluation after exposure to the animal. Method of measurement: The 18-point questionnaire for fear of mice (adapted from the Spider-Man's Questionnaire (FSQ), Szymanski, O’Donohue, 1995).;Serum cortisol level. Timepoint: 1- Baseline measurement 2- Pre-treatment measurement after facing with laboratory rat 3- Post-treatment evaluation after exposure to the animal. Method of measurement: Cortisol measurement by Enzyme-Associated Immunosorbent Assay.;The expression level of IL-1ß encoding gene in white blood cells. Timepoint: 1- Baseline measurement 2- Pre-treatment measurement after facing with laboratory rat 3-Post-treatment evaluation after exposure to the animal. Method of measurement: The expression of this gene relative to a house keeping gene (such as beta-actin) is measured by the Real Time PCR method.;Specific phobic disorder based on DSM-V diagnostic criteria. Timepoint: 1- Baseline measurement 2- Pre-treatment measurement after facing with laboratory rat 3- Post-treatment evaluation after exposure to the animal. Method of measurement: In this study, an anxiety disorder interview (ADIS-IV) is used to diagnose the disorder.	—

Measure

Time frame

Fear of the rat based on mice phobia questionnaire. Timepoint: 1- Baseline measurement 2- Pre-treatment measurement after facing with laboratory rat 3- Post-treatment evaluation after exposure to the animal. Method of measurement: The 18-point questionnaire for fear of mice (adapted from the Spider-Man's Questionnaire (FSQ), Szymanski, O’Donohue, 1995).;Serum cortisol level. Timepoint: 1- Baseline measurement 2- Pre-treatment measurement after facing with laboratory rat 3- Post-treatment evaluation after exposure to the animal. Method of measurement: Cortisol measurement by Enzyme-Associated Immunosorbent Assay.;The expression level of IL-1ß encoding gene in white blood cells. Timepoint: 1- Baseline measurement 2- Pre-treatment measurement after facing with laboratory rat 3-Post-treatment evaluation after exposure to the animal. Method of measurement: The expression of this gene relative to a house keeping gene (such as beta-actin) is measured by the Real Time PCR method.;Specific phobic disorder based on DSM-V diagnostic criteria. Timepoint: 1- Baseline measurement 2- Pre-treatment measurement after facing with laboratory rat 3- Post-treatment evaluation after exposure to the animal. Method of measurement: In this study, an anxiety disorder interview (ADIS-IV) is used to diagnose the disorder.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactCamellia Hemyari

University of social welfare and rehabilitation sciences

camellia.hemyari@gmail.com+98 71 3626 3659

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 26, 2026