Using melatonin pill to reduce the risk of cancer due to exposure to radiation doses from CT imaging .

The investigation radioprotective effect against DNA double-stranded breaks induced in Peripheral blood lymphocytes of patients undergoing CT examinations of the abdomenpelvic of melatonin by immunofluorescence assay

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20171122037593N1

Enrollment

Registered

2019-03-13

Start date

2019-03-10

Completion date

Unknown

Last updated

2019-03-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

.... .

Interventions

Intervention 1: Control group: Patients will be administered only radiation from CT scan and no additional procedures will be done. Intervention 2: Intervention group: This group will be administered

Eligibility

Sex/Gender

All

Age

25 Years to 60 Years

Inclusion criteria

Inclusion criteria: healthy person non-athlete non-smoker non-alcoholic no-radiation therapy no- history of chemotherapy

Exclusion criteria

Exclusion criteria: smoker alcoholic having radiation therapy having chemotherapy

Design outcomes

Primary

Measure	Time frame
Gamma-h2ax foci per cell that represent double strand break( DSB) in cell. Timepoint: Counting the number of DSB in the control group at zero time without taking melatonin and also 1 hour before radiation. Method of measurement: Using the immune fluorescence assay, using gamma-h2ax antibodies and fluorescence microscopy, the number of gamma-h2ax foci is counted.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDR Ali Reza Shirazi

Tehran University of Medical Sciences

shirazia@sina.tums.ac.ir+98 21 6648 2654

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026