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Prolotherapy in Knee Osteoarthritis

Comparison of the effectiveness of intra-articular prolotherapy versus peri-articular prolotherapy on pain reduction and improving function in patients with knee osteoarthritis without effusion

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20171111037396N1
Enrollment
60
Registered
2018-07-18
Start date
2018-08-06
Completion date
Unknown
Last updated
2018-09-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee Osteoarthritis. Bilateral primary osteoarthritis of knee

Interventions

Intervention 1: In the group A patient lies on bed, patient’s knee with placing a pillow under it flexes to 30 degrees then practitioner prepare the knee and injects 5 cc dextrose 25% from inferiolate

Sponsors

Shiraz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
38 Years to 70 Years

Inclusion criteria

Inclusion criteria: Negative Ballottement test Negative Fluid wave test Age from 38 years old to 70 years old of both sex Diagnosed as knee osteoarthritis according to clinical criteria of American College of Rheumatology Having grade 2 and 3 based on Kellgern and Lawrence Grading Scale Complain of pain, crepitation and knee joint stiffness that lasted at least three months before study

Exclusion criteria

Exclusion criteria: Foot deformity Sever genu valgum Any infection involving the knee skin Any intra or peri articular injection during the three last months History of rheumatic or inflammatory disease involving the knee joints Prior total knee arthtoplasty Poorly controlled DM with HbA1c more than 7.5% BMI more than 42 History of knee trauma or fracture during the three last months History of acute lumbosacral radiculopathy or peripheral neuropathy History of cancer Bleeding disorders Pregnancy Severe genu varum

Design outcomes

Primary

MeasureTime frame
Pain. Timepoint: Before injection, 4 and 8 weeks after injection. Method of measurement: Visual Analog Scale (VAS).;Function. Timepoint: Befor injection and 2 and 4 weeks after injection. Method of measurement: The WOMAC consists of 24 items divided into 3 sub scales : Pain (5 items): during walking, using stairs, in bed, sitting or lying, and standing.Stiffness (2 items): after first waking and later in the day.Physical Function (17 items): stair use, rising from sitting, standing, bending, walking, getting in / out of a car, shopping, putting on / taking off socks, rising from bed, lying in bed, getting in / out of bath, sitting, getting on / off toilet, heavy household duties, light household duties.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDashtimakan Hadi

Shiraz University of Medical Sciences

hadidashtimakan@gmail.com+98 71 3233 7855

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026