The effect of scaling and root planning treatment on serum level of IL 23 and IL35 in patients with periodontitis and type 2 diabetes mellitus

Evaluation of the effect of nonsurgical treatment of periodontitis on serum level of IL23 ,35 in periodontitis patients with diabetes type II in comparison with the nondiabetic group: a randomized clinical trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20171108037325N2

Enrollment

Registered

2018-02-20

Start date

2018-02-24

Completion date

Unknown

Last updated

2018-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Type 2 diabetes mellitus. Condition 2: chronic periodontitis. Type 2 diabetes mellitus Chronic periodontitis

Interventions

scaling and root planning.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: patient with type 2 diabetes mellitus and periodontitis

Exclusion criteria

Exclusion criteria: Patients with advanced renal liver and heart failure Patients treated with drugs that increase insulin resistance and increase blood glucose include prednisolone, cyclosporine, and others. Patients who have been taking antibiotics for the last three months or have recieved periodontal treatment Patients with fewer than 14 teeth Pregnant patients Smokers Hemorrhagic diseases Patients with uncontrolled diabetes mellitus (8.5 <HBA1C) who need to increase their dose of oral medication

Design outcomes

Primary

Measure	Time frame
IL23. Timepoint: before intervention/3 months after intervention. Method of measurement: Unit Pg / ml, using Eliza Reader.;IL35. Timepoint: before intervention/3 months after intervention. Method of measurement: Unit Pg / ml, using Eliza Reader.	—

Secondary

Measure	Time frame
Probing depth. Timepoint: befor intervention / 3 months after intervention. Method of measurement: mm unit / periodontal probe.;Clinical attachment loss. Timepoint: before intervention / 3 months after intervention. Method of measurement: mm unit / periodontal probe.;HBA1c. Timepoint: before intervention/3 months after intervention. Method of measurement: No unit / by spectrophotometer.;Bleeding on probing. Timepoint: before intervention / 3 months after intervention. Method of measurement: no unit/using periodontal probe.;Gingival index. Timepoint: before intervention / 3 months after intervention. Method of measurement: score/by obsevation.;Plaque index. Timepoint: before intervention / 3 months after intervention. Method of measurement: score/by observation.;Erythrocyte Sedimentation Rate. Timepoint: before intervention / 3 months after intervention. Method of measurement: no unit/sedimentation tube.;C-Reactive Protein(CRP). Timepoint: before intervention / 3 months after intervention. Method of measurement: Units / By Nephlometric Method.	—

Measure

Time frame

Probing depth. Timepoint: befor intervention / 3 months after intervention. Method of measurement: mm unit / periodontal probe.;Clinical attachment loss. Timepoint: before intervention / 3 months after intervention. Method of measurement: mm unit / periodontal probe.;HBA1c. Timepoint: before intervention/3 months after intervention. Method of measurement: No unit / by spectrophotometer.;Bleeding on probing. Timepoint: before intervention / 3 months after intervention. Method of measurement: no unit/using periodontal probe.;Gingival index. Timepoint: before intervention / 3 months after intervention. Method of measurement: score/by obsevation.;Plaque index. Timepoint: before intervention / 3 months after intervention. Method of measurement: score/by observation.;Erythrocyte Sedimentation Rate. Timepoint: before intervention / 3 months after intervention. Method of measurement: no unit/sedimentation tube.;C-Reactive Protein(CRP). Timepoint: before intervention / 3 months after intervention. Method of measurement: Units / By Nephlometric Method.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr.Avideh Maboudi

Sari University of Medical Sciences

maboodi@mazums.ac.ir+98 11 3326 3345

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026