curcumin-piperine supplementation in children with none- alcoholic fatty liver disease

The effect of curcumin-piperine supplementation on glycemic indices, lipid profiles, anthropometric indices and liver function in children with none- alcoholic fatty liver disease

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20171107037302N2

Enrollment

Registered

2021-11-14

Start date

2021-11-22

Completion date

Unknown

Last updated

2021-11-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

none- alcoholic fatty liver disease. Fatty (change of) liver, not elsewhere classified

Interventions

Intervention 1: Intervention group: Intervention group will receive a capsule containing curcumin-piperine in the amount of 500 mg of curcumin and 5 mg of piperine once a day for 10 weeks. Interventio

Eligibility

Sex/Gender

All

Age

10 Years to 18 Years

Inclusion criteria

Inclusion criteria: diagnosis of NAFLD (grades 1–3) according to liver ultrasonography children with BMI percentile>=85 for age age 10-18 years old

Exclusion criteria

Exclusion criteria: presence of hepatitis, Chronic liver disease , Cardiovascular, renal, Pulmonary, Hypothyroidism diseases and cancer not consuming drugs that could affect on ALT level including HMG-COA reductase inhibitors, metformin

Design outcomes

Primary

Measure	Time frame
Weight. Timepoint: At the beginning of study - week 10. Method of measurement: Seca scale.;Height. Timepoint: At the beginning of study - week 10. Method of measurement: Strip meter.;Waist circumference. Timepoint: At the beginning of study - week 10. Method of measurement: strip meter.;Hip circumference. Timepoint: At the beginning of study - week 10. Method of measurement: strip meter.;Body mass index. Timepoint: At the beginning of study - week 10. Method of measurement: formula.;Fasting blood sugar. Timepoint: At the beginning of study - week 10. Method of measurement: biochemical assessment.;Triglycerides. Timepoint: At the beginning of study - week 10. Method of measurement: biochemical assessment.;Low-density lipoprotein. Timepoint: At the beginning of study - week 10. Method of measurement: biochemical assessment.;High-density lipoprotein. Timepoint: At the beginning of study - week 10. Method of measurement: biochemical assessment.;Total cholesterol. Timepoint: At the beginning of study - week 10. Method of measurement: biochemical assessment.;Alanine aminotransferase. Timepoint: At the beginning of study - week 10. Method of measurement: biochemical assessment.;Aspartate aminotransferase. Timepoint: At the beginning of study - week 10. Method of measurement: biochemical assessment.	—

Measure

Time frame

Weight. Timepoint: At the beginning of study - week 10. Method of measurement: Seca scale.;Height. Timepoint: At the beginning of study - week 10. Method of measurement: Strip meter.;Waist circumference. Timepoint: At the beginning of study - week 10. Method of measurement: strip meter.;Hip circumference. Timepoint: At the beginning of study - week 10. Method of measurement: strip meter.;Body mass index. Timepoint: At the beginning of study - week 10. Method of measurement: formula.;Fasting blood sugar. Timepoint: At the beginning of study - week 10. Method of measurement: biochemical assessment.;Triglycerides. Timepoint: At the beginning of study - week 10. Method of measurement: biochemical assessment.;Low-density lipoprotein. Timepoint: At the beginning of study - week 10. Method of measurement: biochemical assessment.;High-density lipoprotein. Timepoint: At the beginning of study - week 10. Method of measurement: biochemical assessment.;Total cholesterol. Timepoint: At the beginning of study - week 10. Method of measurement: biochemical assessment.;Alanine aminotransferase. Timepoint: At the beginning of study - week 10. Method of measurement: biochemical assessment.;Aspartate aminotransferase. Timepoint: At the beginning of study - week 10. Method of measurement: biochemical assessment.

—

Secondary

Measure	Time frame
Fasting insulin. Timepoint: At the begining of study - week 10. Method of measurement: biochemical assessment.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSahar Saraf-Bank

Esfahan University of Medical Sciences

saraf2shr@yahoo.com+98 31 3792 3172

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026