Efficacy of quetiapine in methamphetamine dependency

The Survey effect of quetiapine on methamphetamine abuse in patients Methadone Maintenance Treatment

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20171106037290N1

Enrollment

Registered

2017-11-25

Start date

2017-10-17

Completion date

Unknown

Last updated

2019-11-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Methamphetamine dependence. Mental and behavioural disorders due to use of other stimulants, including caffeine

Interventions

Intervention 1: Intervention group: Quetiapine 100 mg daily for 8 weeks. Intervention 2: Control group: Placebo for 8 weeks.

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Aged 18–65 years History of MA and opioid co-abuse in the past year Currently undergoing methadone maintenance treatment Seeking treatment for MA abuse Evaluated by the drug abuse section of the Structured Clinical Interview for DSM-IV

Exclusion criteria

Exclusion criteria: Suicide attempts within the past 6 months or either suicidal ideations or psychotic symptoms in the past 6 months as determined by a study physician Current alcohol or sedative physical dependence or cocaine dependence Major cardiovascular disturbance Metabolic diseases (e.g., neurological diseases and diabetes).

Design outcomes

Primary

Measure	Time frame
Negative urine test for methamphetamine. Timepoint: Once every fifteen days. Method of measurement: methamphetamine urine test.;Depression. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Beck Depression Inventory (BDI).;Anxiety. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Beck Anxiety Inventory (BAI).;Sleep quality. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Pittsburgh Sleep Quality Index (PSQI).;Craving. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Desire for Drug Questionnaire (DDQ craving).;Withdrawal. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Amphetamine Withdrawal Questionnaire (AWQ).	—

Measure

Time frame

Negative urine test for methamphetamine. Timepoint: Once every fifteen days. Method of measurement: methamphetamine urine test.;Depression. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Beck Depression Inventory (BDI).;Anxiety. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Beck Anxiety Inventory (BAI).;Sleep quality. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Pittsburgh Sleep Quality Index (PSQI).;Craving. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Desire for Drug Questionnaire (DDQ craving).;Withdrawal. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Amphetamine Withdrawal Questionnaire (AWQ).

—

Secondary

Measure	Time frame
Risky Decision Making. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Iowa Gambling Task (IGT).;Memory. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Wechsler Logic Memory.;Verba Fluency. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: FAS task.;Speed Processing. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Digit Symbol and Trial Making Test (TMT).	—

Measure

Time frame

Risky Decision Making. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Iowa Gambling Task (IGT).;Memory. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Wechsler Logic Memory.;Verba Fluency. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: FAS task.;Speed Processing. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Digit Symbol and Trial Making Test (TMT).

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNajmesadat Javdan

Kashan University of Medical Sciences

javdan-na@kaums.ac.ir+98 31 5554 0021

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026