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The effect of ketamine and midazolam combination in comparison to ketamine and morphine for pain treatment

Comparison of the effects of ketamine and midazolam combination with ketamine and morphine for acute pain management at emergency department

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20171106037280N2
Enrollment
168
Registered
2018-02-21
Start date
2017-11-14
Completion date
Unknown
Last updated
2018-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute pain in emergency department. Acute pain, not elsewhere classified

Interventions

Intervention 1: Intervention group 1: ketamine: ketamine 0.3 mg/kg IV infusion over 3-5 min (Rotexmedica drug company, ketamine hydrochloride), administered once at the beginning of the intervention.

Sponsors

kurdistan university of medical sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 55 Years

Inclusion criteria

Inclusion criteria: moderate to severe pain acute pain at emergency department age 18-55

Exclusion criteria

Exclusion criteria: allergy to drugs pregnancy or lactation elevated intracerebral or intraocular pressure chronic pain

Design outcomes

Primary

MeasureTime frame
Pain intensity. Timepoint: 15,30,60,90, and 120 min after drug adminidtrstion. Method of measurement: numeric rating scale (NRS).

Secondary

MeasureTime frame
Changes in blood pressure. Timepoint: 15,30,60,90, and 120 min after drug administration. Method of measurement: measurement of blood pressure by the sphygmomanometer.;Nausea and vomiting. Timepoint: from beginning to the end (120 min after drug administration). Method of measurement: observation.;Dizziness. Timepoint: from beginning to the end (120 min after drug administration). Method of measurement: history taking and asking from the patient.;Behavioral change. Timepoint: from drug administration to 120 min afterwards. Method of measurement: observation.;Delusion and hallucinations. Timepoint: from drug administration to 120 min afterwards. Method of measurement: observation and history taking.;Changes in O2 saturation. Timepoint: from drug administration to 120 min afterwards. Method of measurement: continuous pulse oximetry.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHamed Sotoude

Kurdstan University of Medical Sciences

H-sotude@razi.tums.ac.ir+98 87 3366 2027

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026