Effect of Remote Ischemic Preconditioning on the Incidence of Acute Kidney Injury in Patients Undergoing Coronary Artery Bypass Graft Surgery

Effect of Remote Ischemic Preconditioning on the Incidence of Acute Kidney Injury in Patients Undergoing Coronary Artery Bypass Graft Surgery: A Randomized Controlled Trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017110537254N1

Enrollment

180

Registered

2017-11-09

Start date

2013-11-02

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Acute kidney injury. Condition 2: Remote ischemic preconditioning. Condition 3: Coronary artery bypass graft surgery.

Interventions

Intervention 1: Intervention: RIPC Patients in the remote ischemic preconditioning (RIPC) group will receive three sequential sphygmomanometer cuff inflations on their right upper arm after induction

Prevention

Placebo

Intervention: RIPC Patients in the remote ischemic preconditioning (RIPC) group will receive three sequential sphygmomanometer cuff inflations on their right upper arm after induction of anesthesia i

Control: sham-RIPC Patients in the sham-RIPC group will have the sphygmomanometer cuff placed on their right upper arm, but the cuff will not be inflated. Similar to patients in the RIPC group, patie

Eligibility

Sex/Gender

All

Age

18 Years to 85 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria: • Candidate cardiac surgical patients • Elective or urgent on pump coronary artery bypass grafting (CABG) • Age 18 to 85 years • Signed informed consent Exclusion Criteria: • End-stage renal disease (receiving hemodialysis or glomerular filtration rate <15 ml/min/1.73m2) • Peripheral vascular disease • Severe hepatic disease • Planned off-pump surgery • Pregnancy

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Incidence of postoperative acute kidney injury (AKI). Timepoint: Within the first 72 hours after surgery. Method of measurement: Defined as an elevation of serum creatinine of =0.3 mg/dl or =50% within 72 hours after surgery.	—

Secondary

Measure	Time frame
Duration of hospital stay. Timepoint: Through hospital stay after surgery. Method of measurement: in days.;Duration of ICU stay. Timepoint: Through ICU stay. Method of measurement: in days.;All cause mortality. Timepoint: Through hospital stay after surgery. Method of measurement: number of observed cases.;Requiring hemodialysis. Timepoint: Through hospital stay after surgery. Method of measurement: number of observed cases.;Postoperative liver function. Timepoint: Preoperatively and at 24 h post-surgery. Method of measurement: By measuring serum AST, ALT, T.bilirubin, and albumin.;Incidence of postoperative atrial fibrillation (AF). Timepoint: Within the first 72 hours after surgery. Method of measurement: Defined as the incidence of new-onset AF lasting for five minutes or longer.;Incidence of postoperative stroke. Timepoint: Through hospital stay after surgery. Method of measurement: Defined as a new ischemic or hemorrhagic cerebrovascular accident with neurological deficit lasting >24 h.	—

Measure

Time frame

Duration of hospital stay. Timepoint: Through hospital stay after surgery. Method of measurement: in days.;Duration of ICU stay. Timepoint: Through ICU stay. Method of measurement: in days.;All cause mortality. Timepoint: Through hospital stay after surgery. Method of measurement: number of observed cases.;Requiring hemodialysis. Timepoint: Through hospital stay after surgery. Method of measurement: number of observed cases.;Postoperative liver function. Timepoint: Preoperatively and at 24 h post-surgery. Method of measurement: By measuring serum AST, ALT, T.bilirubin, and albumin.;Incidence of postoperative atrial fibrillation (AF). Timepoint: Within the first 72 hours after surgery. Method of measurement: Defined as the incidence of new-onset AF lasting for five minutes or longer.;Incidence of postoperative stroke. Timepoint: Through hospital stay after surgery. Method of measurement: Defined as a new ischemic or hemorrhagic cerebrovascular accident with neurological deficit lasting >24 h.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSina Bagheri

Shiraz nephro-urology research center

bagherisi@sums.ac.ir+98 71326281563

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026