Effect of Crocin in treatment of methadone maintenance treatment patients

Effect of Crocin on psychological symptoms in methadone maintenance treatment patients

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017110537243N1

Enrollment

Registered

2017-11-19

Start date

2017-11-01

Completion date

Unknown

Last updated

2019-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mental & behavioural disorders due to use of opioids. Mental and behavioural disorders due to use of opioids

Interventions

Intervention 1: Intervention group: tablet of Crocin, 15 mg, two oral tablet for 8 weeks. Intervention 2: Control group: Placebo tablet, two oral tablet for 8 weeks.

Eligibility

Sex/Gender

Male

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Diagnosis of substance dependency based on DSM-IV Age of 18 to 60 years old Patients’ willingness to participate in the intervention Patients of maintenance methadone treatment

Exclusion criteria

Exclusion criteria: Taking crocin, multivitamin-mineral and antioxidant supplements during the last 3 months before the intervention initiation History of metabolic diseases including diabetes, hypertension, thyroid and cardiovascular disease

Design outcomes

Primary

Measure	Time frame
Depression beck score. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Questionnaire.	—

Secondary

Measure	Time frame
Side effect of Crocin. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Side effect evaluation questionnaire.;Anxiety beck score. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Questionnaire.;General health. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Questionnaire (GHQ).;Sleep quality. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Questionnaire (PSQI).;Sexual function. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Questionnaire (IIEF).	—

Measure

Time frame

Side effect of Crocin. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Side effect evaluation questionnaire.;Anxiety beck score. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Questionnaire.;General health. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Questionnaire (GHQ).;Sleep quality. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Questionnaire (PSQI).;Sexual function. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Questionnaire (IIEF).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAbdollah Omidi

Kashan University of Medical Sciences

omidi-a@kums.ac.ir+98 31 5546 3378

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Mar 4, 2026