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A Comparative Study on the Effect of Prescribing Dexmedetomidine with Haloperidol in Preventing Delirium

A Comparative Study on the Effect of Prescribing Dexmedetomidine with Haloperidol in Preventing Delirium after Coronary Artery Bypass Graft surgery in Chamran Hospital? 2016-2017

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20171104037209N1
Enrollment
100
Registered
2017-11-29
Start date
2016-10-22
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

?Delirium. Other delirium Delirium of mixed origin Postoperative delirium

Interventions

Intervention 1: Intervention group: were put under dexmedetomidine 1 microgram per kilogram during 10 minutes and preserver infusion of 0.2 to 0.7 Micrograms per hour per kilogram until the separation
Treatment - Drugs
Intervention group: were put under dexmedetomidine 1 microgram per kilogram during 10 minutes and preserver infusion of 0.2 to 0.7 Micrograms per hour per kilogram until the separation of the ventilat
Control group: were put under intramuscular haloperidol 0.5 milligram in case of agitation

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: The entrance criterion included the patients who were candidates for open surgery of coronary arteries and referred to Shahid Chamran Hospital participate in the study And were free from any psychiatric disease or dementia He candidates had agreed to participate in the study

Exclusion criteria

Exclusion criteria: lack of candidate’s assistance Shortages in data under study The patient’s death during the surgery or by entrance to ICU Need to do the surgery again due to bleeding after entrance to ICU Excessive allergy to haloperidol and phenothiazine Parkinson (trembling at the time of rest) and weakness in CNS Glaucoma Seizure anamnesis Getting anti-seizure, anti-Parkinson, or lithium drugs

Design outcomes

Primary

MeasureTime frame
Delirium? Delirium Exposure? Blood Pressure? During Hospital Occupation? Laboratory variables (sodium and potassium? and variables ABG). Timepoint: Before entering ICU? Before the pump? During the pump? After the pump? The first day of the ICU? The second day of the ICU? Third day of the ICU. Method of measurement: Delirium demonstration by the Richmond Agitation-Sedation Scale Severity of delirium using CAM-ICU Duration of the pump in minutes using the timer The duration of admission to the ICU by day using the count of the days Average arterial blood pressure using a mercury pressure gauge device Receiving haloperidol in the event of delirium with patient file information The amount of pack cell received using patient file information Laboratory variables through blood sampling and determination of laboratory values.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Gholamreza Masoumi

Esfahan University of Medical Sciences

massoumigh@mui.ac.ir+98 31 3260 0961

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026