Chicory gel effect on the treatment of osteoarthritis

comparsion of the effects of 3% Cichorium intybus L. hydroalcoholic extract gel vs diclofenac gel in the treatment of patients with primary monoarticular knee osteoarthritis who are taking celecoxib.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017103037093N1

Enrollment

150

Registered

2017-11-20

Start date

2017-12-03

Completion date

Unknown

Last updated

2019-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee osteoarthritis. Other primary gonarthrosis

Interventions

Intervention 1: Negative control group: Patients with primary monoarticular osteoarthritis of knee joint who take 200 mg celecoxib tablets once a day and use the gel containing the base of the gel (p

Eligibility

Sex/Gender

All

Age

40 Years to 80 Years

Inclusion criteria

Inclusion criteria: age of 40-80 years weight of 50-80 kgs primary osteoarthritis in one knee, confirmed by radiological criteria in knee graphy secondary osteoarthritis or suspecting to it lack of history of cognitive impairment lack of Liver,kidney or any other underlying disease having no history of allergies

Exclusion criteria

Exclusion criteria: primary osteoarthritis in both knees history of allergy to any form of anti-inflammatory drugs skin diseases,infection or ulcers at the site of topical use of the drug use of other topical drugs at the place of use of the drug use of aromatase inhibitors the oral administration of other analgesics and other compounds effective in the treatment of osteoarthritis up to 10 days before the start of the study congenital joint diseases pregnancy lack of cooperation and desire of the individual during the study to continue the company creation of any Sensitivity or any problem during the intervention

Design outcomes

Primary

Measure	Time frame
Knee pain. Timepoint: Before intervention, 6 weeks after intervention. Method of measurement: Western Ontario & McMaster Universities Osteoarthritis Index & Visual Analogue Scale questionnaire.;Daytime stiffness. Timepoint: Before intervention, 6 weeks after intervention. Method of measurement: Western Ontario & McMaster Universities Osteoarthritis Index questionnaire.;Morning stiffness. Timepoint: Before intervention, 6 weeks after intervention. Method of measurement: Western Ontario & McMaster Universities Osteoarthritis Index questionnaire.;Physical performance. Timepoint: Before intervention, 6 weeks after intervention. Method of measurement: Western Ontario & McMaster Universities Osteoarthritis Index questionnaire.	—

Measure

Time frame

Knee pain. Timepoint: Before intervention, 6 weeks after intervention. Method of measurement: Western Ontario & McMaster Universities Osteoarthritis Index & Visual Analogue Scale questionnaire.;Daytime stiffness. Timepoint: Before intervention, 6 weeks after intervention. Method of measurement: Western Ontario & McMaster Universities Osteoarthritis Index questionnaire.;Morning stiffness. Timepoint: Before intervention, 6 weeks after intervention. Method of measurement: Western Ontario & McMaster Universities Osteoarthritis Index questionnaire.;Physical performance. Timepoint: Before intervention, 6 weeks after intervention. Method of measurement: Western Ontario & McMaster Universities Osteoarthritis Index questionnaire.

—

Secondary

Measure	Time frame
Skin allergy. Timepoint: Six weeks after the intervention. Method of measurement: Observation and examination.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMorteza Dehghan

Shahrekord University of Medical Sciences

dehghan_mortaza@yahoo.com+98 38 3227 4004

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026