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Effect of Xylitol nasal spray in treatment of chronic rhinosinusitis

Evaluation of the effect of Xylitol nasal spray in treatment of patients with chronic rhinosinusitis

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20171030037093N35
Enrollment
30
Registered
2020-04-11
Start date
2020-04-07
Completion date
Unknown
Last updated
2020-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rhinosinusitis. Chronic sinusitis, unspecified

Interventions

Intervention 1: Intervention group: xylitol nasal spray intervention group is given two puffs every 8 hours for 30 days. Intervention 2: Control group: The second group, or placebo, received normal sa

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients with chronic rhinosinusitis Age over 18 years They had previously undergone sinus endoscopy and now need only non-surgical treatments.

Exclusion criteria

Exclusion criteria: Patients who have a history of allergic rhinitis, asthma, immunodeficiency, cystic fibrosis, primary pulmonary dyskinesia, active bacterial or fungal infection and need antibiotics or antifungals Patients who are unsatisfied with non-surgical treatment or want to have surgery again for any reason Have a history of head and neck radiation therapy Now be a smoker Pregnant people Have granulomatous disease

Design outcomes

Primary

MeasureTime frame
Lund Kennedy Score. Timepoint: Before and after the study. Method of measurement: Lund Kennedy questionnaire.;SNOT 22 (Sino-nasal Outcome Test) score. Timepoint: Before the intervention and 30 days after the intervention. Method of measurement: SNOT 22 (Sino-nasal Outcome Test).;Severe pain when pressing on the sinuses. Timepoint: Before and after the study. Method of measurement: VAS (Visual Analog Scale) questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAhmad Rezaeian

Esfahan University of Medical Sciences

ahmadrezaeian@med.mui.ac.ir+98 31 3556 5175

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026