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The effect of cocoa powder on fatigue in multiple sclerosis patients

Investigation of the effect of cocoa powder on fatigue severity in patients with multiple sclerosis(MS) in comparison with placebo effect

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20171030037093N34
Enrollment
60
Registered
2020-03-28
Start date
2020-03-30
Completion date
Unknown
Last updated
2020-04-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple sclerosis. Multiple sclerosis

Interventions

Intervention 1: Intervention group: The drug will be administered in the form of 12.5 grams of cocoa powder after dissolving in a glass of water half an hour before or one hour after meals. Interventi

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 50 Years

Inclusion criteria

Inclusion criteria: Consent to participate in the study MS with Relapsing remitting form Less than 10 years have passed since their diagnosis Age between 20 and 50 years Have a Fatigue severity scale above 4. The EDSS score is below 6 Have a recent anemia and hypothyroid rejection test in one month

Exclusion criteria

Exclusion criteria: Have recurrent in the past 3 months The disease involves the CNS except migraine They have acute febrile illness Have systemic autoimmune disease Based on Beck Depression Inventory moderate or severe (Questionnaire score above 20) Currently taking neurotoxic drugs including: antipsychotic agents, monoamine oxidase inhibitors, benzodiazepines, tricyclic antidepressant drugs, anticonvulsants, beta blockers and barbiturates

Design outcomes

Primary

MeasureTime frame
Fatigue. Timepoint: Before and after the study. Method of measurement: With MFIS and FSS questionnaires.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactIman Adibi

Esfahan University of Medical Sciences

i.adibi@gmail.com+98 31 3792 7539

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026