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Evaluation of the effect of sodium valproate and Levetiracetam on the prevention of migraine headaches

Comparison of the effect of sodium valproate and Levetiracetam on the prevention of migraine headaches

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20171030037093N14
Enrollment
80
Registered
2019-07-02
Start date
2019-07-23
Completion date
Unknown
Last updated
2019-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

migraine. Migraine

Interventions

Intervention 1: Intervention group: The first group received 500 mg of levetiracetam per day. Intervention 2: Intervention group: The second group received 500 mg/day sodium sulfate.

Sponsors

Shahre-kord University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Age 18 to 65 years old Migraine headache history for at least 6 months before study based on IHS criteria Moderate to severe headache for less than 6 days with Visual Analogue Scale Natural Signs and Natural Nerve Findings.

Exclusion criteria

Exclusion criteria: Patients with kidney failure, liver disease, heart disease, active stomach ulcer disease or diabetes or abnormal vital symptoms Allergy to valproate and Levetiracetam Pregnant or lactating women Cases of other types of headaches such as sinus headaches Taking nonsteroidal anti-inflammatory drugs within 24 hours or valproate over the past 2 weeks

Design outcomes

Primary

MeasureTime frame
Headache severity. Timepoint: Before the start of the study, notes were taken every 30 days. Method of measurement: Based on VAS and doctor.;Number of headaches per month. Timepoint: Before the start of the study, notes were taken every 30 days. Method of measurement: MIDAS questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammadhosein Saffari

Shahre-kord University of Medical Sciences

Dr.safari@gmail.com+98 38 3224 2696

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026