The effect of amitriptyline, ketamine and Baclofen gel for pain relief after mastectomy

Investigation on the effect of topical amitriptyline, ketamine and Baclofen gel for pain relief after mastectomy in patients with breast cancer

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20171030037093N13

Enrollment

Registered

2019-05-25

Start date

2019-06-22

Completion date

Unknown

Last updated

2019-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mastectomy. Encounter for breast reconstruction following mastectomy

Interventions

Intervention 1: Intervention first group: Daily, a baclofen-amitriptyline-ketamine combination gel twice a day (morning and night) at a dose of 1.3 g, is equivalent to one tbsp of topical. Interventio

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Pain syndrome after mastectomy At least 1 month has passed surgery Not having other neuropathic conditions, such as shingles and diabetic neuropathy

Exclusion criteria

Exclusion criteria: The presence of open sore in the surgical site Taking painkillers

Design outcomes

Primary

Measure	Time frame
Quality of life. Timepoint: Before and 4 weeks after study. Method of measurement: SF 36 questionnaire.;Irritation. Timepoint: Before and 4 weeks after study. Method of measurement: Check list.;Anesthesia. Timepoint: Before and 4 weeks after study. Method of measurement: Check list.;Pain. Timepoint: Before and 4 weeks after study. Method of measurement: VAS benchmark.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactRohollah Masoumi

Shahre-kord University of Medical Sciences

Rmasomi@gmail.com+98 913 284 1574

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026