Apnoea. Primary sleep apnoea of newborn
Conditions
Interventions
Intervention 1: Control received no caffeine. Intervention 2: Infants of intervention group on the second day of birth (24-48 h) intravenous caffeine citrate with a dose of 20mg/kg and then the mainte
Placebo
Treatment - Drugs
Control received no caffeine.
Infants of intervention group on the second day of birth (24-48 h) intravenous caffeine citrate with a dose of 20mg/kg and then the maintenance dose 24 hours after the first injection with a dose of 5
Sponsors
Urmia University of Mecidal Sciences
Eligibility
Sex/Gender
All
Age
1 Days to 8 Months
Inclusion criteria
Inclusion criteria: Inclusion criteria for entering were the premature newborns weighing less than 1500 grams at least 24 hours of age and having self-contained breathing in the first 24 hours of life; and exclusion criteria were maternal major anomalies, the incidence of apnea in the first 24 hours of life and the need for mechanical ventilation in 24 The first hour of birth, cyanotic heart disease, small age for gestational age (SGA, IUGR), intrauterine growth retardation, as well as clinical evidence for sepsis during the first 7 days of birth and IVH grade 3 or 4 during the first week of life.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Apnoea. Timepoint: From beginning to end of intervention. Method of measurement: The number of cases of apnea reported by the nurse. | — |
Secondary
| Measure | Time frame |
|---|---|
| Bradicardia. Timepoint: From beginning to end of intervention. Method of measurement: The number of cases of bradicardia reported by the nurse.;Cyanosis. Timepoint: From beginning to end of intervention. Method of measurement: The number of cases of cyanosis reported by the nurse.;Duration of oxygen demand. Timepoint: From beginning to end of intervention. Method of measurement: Duration of oxygen demand reported by the nurse.;Duration of NCPAP demand. Timepoint: From beginning to end of intervention. Method of measurement: Duration of NCPAP demand reported by the nurse.;Duration of mechanical ventilation demand. Timepoint: From beginning to end of intervention. Method of measurement: Duration of mechanical ventilation demand reported by the nurse.;Hospitalization. Timepoint: From beginning to end of intervention. Method of measurement: Patients' Records. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Zahra Fakoor
Urmia University of Medical Sciences
Outcome results
None listed