Condition 1: Coronary artery disease. Condition 2: Coronary artery bypass graft. Atherosclerotic heart disease Mechanical complication of coronary artery bypass and valve grafts
Conditions
Interventions
Intervention 1: Intervention group: Mostly crystalloid cardioplegia (2% blood to prevent obscuring of the operative field), is infused continuously through vein grafts by a separate infusion set, onc
Treatment - Surgery
Control group: Antegrade cold blood cardioplegia (at a ratio of 4 to 1) is infused via aortic root by means of a cannula inserted by the surgeon at the middle part of ascending aorta. This injection c
Intervention group: Mostly crystalloid cardioplegia (2% blood to prevent obscuring of the operative field), is infused continuously through vein grafts by a separate infusion set, once each distal an
Sponsors
Vice chancellor for research and technology, Arak University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria: Coronary artery disease patients scheduled for first-time elective isolated on-pump CABG Exclusion criteria: 1. Redo CABG 2. Urgent CABG 3. Off-pump CABG 4. Combined operations including CABG in addition to valve repair or replacement 5. Unexpected intra-operative complications e.g. aortic rupture during cannulation
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The need for balloon pump. Timepoint: During and after weaning. Method of measurement: Number (percentage).;The need for inotrope. Timepoint: During and after weaning. Method of measurement: Number (percentage). | — |
Secondary
| Measure | Time frame |
|---|---|
| Other complications including neurologic, renal, and pulmonary complications. Timepoint: Within one month after surgery. Method of measurement: Number (percentage).;The amount of bleeding. Timepoint: Within 24 hours following surgery. Method of measurement: mL.;Serum level of potassium. Timepoint: Immediately upon arrival to ICU. Method of measurement: mEq/L.;The rate of perioperative myocardial infarction. Timepoint: During hospitalization. Method of measurement: Number (percentage).;Hospital mortality. Timepoint: During hospitalization. Method of measurement: Number (percentage).;The rate of postoperative arrhythmia. Timepoint: During ICU stay. Method of measurement: Number (percentage).;Peak serum level of CK, CK-MB, and cTnI. Timepoint: At 12 hours following operation in the ICU. Method of measurement: mcg/L.;The rate of superficial or deep wound infection. Timepoint: During hospitalization. Method of measurement: Number (percentage).;The rate of re-exploration due to hemorrhage or tamponade. Timepoint: Within 24 hours following surgery in the ICU. Method of measurement: Number (percentage).;Ventilation time. Timepoint: Within 24 hours following surgery in the ICU. Method of measurement: Hours.;Arterial level of base excess (BE). Timepoint: Within one hour after arrival to ICU. Method of measurement: mmol/L.;Duration of ICU stay. Timepoint: following surgery. Method of measurement: Days.;Duration of hospital stay. Timepoint: following surgery. Method of measurement: Days. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMehrzad Sharifi
Arak University of Medical Sciences
Outcome results
None listed