Evaluating a protocol of antibiotic prophylaxis to reduce bacterial contamination of the bone particles collected directly from the burs used for preparation of the dental implant site

The role of antibiotic prophylaxis in reducing bacterial contamination of autologous bone graft collected from implant site

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017102537002N1

Enrollment

Registered

2017-11-14

Start date

2014-09-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bacterial contamination of autologous bone particles collected from dental implant site. *

Interventions

Intervention 1: TEST Intervention: Antibiotic prophylaxis is prescribed to the Test group patients. One 1 gr. tablet of amoxicillin + clavulanic acid (Augmentin, GlaxoSmithKline, Verona, Italy) is giv

Treatment - Drugs

TEST Intervention: Antibiotic prophylaxis is prescribed to the Test group patients. One 1 gr. tablet of amoxicillin + clavulanic acid (Augmentin, GlaxoSmithKline, Verona, Italy) is given to the test g

CONTROL Intervention: The Control group patients do not take antibiotic prophylaxis at all (No intervention). All patients (Test and Control groups) will undergo the same surgical procedure (ie, impla

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: The study is conducted in healthy human volunteers. Inclusion criteria: a need to replace the absence of one tooth with an implant supported prosthesis, no systemic diseases or contraindications to surgical procedures, no pregnancy, no routine drug use, no history of antibiotic therapy for 6 months prior to the study, no allergy to penicillin or related drugs, absence of carious lesions and local active inflammatory conditions or chronic/aggressive periodontits, presence of alveolar ridges of class II or III of Cawood and Howell (1988). Exclusion criteria: systemic diseases that affect jaws and periodontium; orthodontic appliance; active dental caries; chronic diseases of the oral mucosa; chronic antibiotic usage; antiplaque mouthrinse consumption; drugs consumption which affect saliva flow rate; radiotherapy history.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Reduction of bacterial contamination. Timepoint: Following end of treatment (antibiotic prophylaxis), during implant site preparation. Method of measurement: Counts (CFU) and identification of isolated bacteria.	—

Countries

Italy

Contacts

Public ContactGiuseppe Pizzo

University of Palermo

giuseppe.pizzo@unipa.it00390916552221

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 27, 2026