Condition 1: Disorders of vitreous body. Condition 2: postprocedural pain. Disorders of vitreous body Pain during the period after surgery.
Conditions
Interventions
Intervention 1: Patients in second group will receive placebo before induction and then undergo general anesthesia. Intervention 2: Patients in group one will receive 30 mg dextromethorphan orally bef
Placebo
Treatment - Drugs
Patients in second group will receive placebo before induction and then undergo general anesthesia
Patients in group one will receive 30 mg dextromethorphan orally before induction and then undergo general anesthesia
Sponsors
Vice-Chancellor of research Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
35 Years to 75 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: all patients between 35 to 75 years old; with ASA classes I and II; undergoing vitrectomy under general anesthesia; Exclusion criteria: Obese patients; History of opioid consumption within 48 hours of surgery; sedatives or centrally acting drugs use (central nervous system depressants or antidepressants) 21 days prior to surgery; those with a history of chronic pain; psychotic disorders or addiction including opioids; those with any contraindications to dextromethorphan; and pregnant or lactating women.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain. Timepoint: after surgery in recovery, 1, 2 and 6 hours after surgery. Method of measurement: using visual analogue scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Sedation rate. Timepoint: after surgery in recovery, 1, 2 and 6 hours after surgery. Method of measurement: using Ramsy sedation assessment scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactPoopak Rahimzadeh
Rasool Akram Hospital
Outcome results
None listed