Effect of green tea pills and metformin versus placebo on the Nrf2-antioxidant system and proinflammatory cytokines, including IL-6 and TNF-a, in peripheral blood mononuclear cells of women with polycystic ovary syndrome

Effect of green tea pills and metformin versus placebo on the Nrf2-antioxidant system and proinflammatory cytokines, including IL-6 and TNF-a, in peripheral blood mononuclear cells of women with polycystic ovary syndrome: a single blind randomized clinical trial

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT201710219014N197

Enrollment

120

Registered

2017-11-06

Start date

2017-11-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Polycystic ovarian syndrome. Polycystic ovarian syndrome

Interventions

Intervention 1: Intervention group 1: Tablet green tea 1500 mg 3 times a day for 90 days. Intervention 2: Intervention group 2: Tablet metformin 1500 mg 3 times a day for 90 days. Intervention 3: Cont

Treatment - Drugs

Placebo

Intervention group 1: Tablet green tea 1500 mg 3 times a day for 90 days.

Intervention group 2: Tablet metformin 1500 mg 3 times a day for 90 days.

Control group: Tablet Placebo (including starch) 3 times a day for 90 days.

Eligibility

Sex/Gender

Female

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Women in age of 18 to 40 years; polycystic ovary syndrome; insulin resistant; oligoavolation; having several ovarian cyst (follicle with diameter of 2 to 6 mm); irregular period. Exclusion criteria: Cardiovascular diseases; mental disorders; hyperthyroiditis; gastrointestinal disorders; sensitivity to caffeine; occurrence of pregnancy.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Measuring Nrf2-antioxidant system. Timepoint: Before intervention and 90days after that. Method of measurement: Through laboratory test.;Measuring proinflammatory cytokines including IL-6 and TNF-a. Timepoint: Before intervention and 90 days after that. Method of measurement: Through laboratory test.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAmir Barati Mosleh

School of Nursing and Midwifery

baratiamir64@gmail.com+98 81 3838 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026