Effect of Acetaminophen and Dexamethasone on agitation in tonsillectomy children

Study of Acetaminophen and Dexamethasone effects on agitation in children undergoing tonsillectomy

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20171016036817N1

Enrollment

140

Registered

2017-12-22

Start date

2017-12-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tonsil's inflammation. Tonsil, unspecified

Interventions

Intervention 1: Intervention Group 1:Receiving Dexamethasone and placebo acetaminophen (Dexamethasone At the request of the hospital's drugstore intravenously 0.2 mg / kg in addition to 0.25 mg / kg o

Treatment - Drugs

Placebo

Control group: Receiving dexamethasone placebo and acetaminophen placebo (normal saline 0.5 ml / kg plus 0.25 mg / kg of syrup with strawberry flavor)

Intervention Group 1:Receiving Dexamethasone and placebo acetaminophen (Dexamethasone At the request of the hospital's drugstore intravenously 0.2 mg / kg in addition to 0.25 mg / kg of syrup with str

Intervention group2: Receiving Acetaminophen and Dexamethasone placebo (20 mg per kg of acetaminophen syrup At the request of the hospital's drugstore with 0.5 ml / kg of normal saline)

Intervention group3: Receiving Acetaminophen and Dexamethasone (20 mg / kg acetaminophen syrup At the request of the hospital's drugstore with 0.2 mg / kg intravenous dexamethasone At the request of t

Eligibility

Sex/Gender

All

Age

2 Years to 7 Years

Inclusion criteria

Inclusion criteria: Parents are satisfied with entering the study All children aged 2 to 7 years undergoing tonsillectomy

Exclusion criteria

Exclusion criteria: Those who have taken previous medications (all previous medications should be removed within 2 hours before the surgery)

Design outcomes

Primary

Measure	Time frame
Agitation. Timepoint: Prior to admission, pain is measured by face scale and children's agitation will measured by the Richmond Agitation Sedation Score. The two cases are also measured after admission and receiving drugs in the PICU, as well as 10, 20, and 30 minutes after extubation of the tube tract. (0: vigilant and calm, 1: restless, 2: disturbed, 3: very disturbed and 4: controversy and fights). Method of measurement: pain is measured by face scale and children's agitation will measured by the Richmond Agitation Sedation Score.	—

Measure

Time frame

Agitation. Timepoint: Prior to admission, pain is measured by face scale and children's agitation will measured by the Richmond Agitation Sedation Score. The two cases are also measured after admission and receiving drugs in the PICU, as well as 10, 20, and 30 minutes after extubation of the tube tract. (0: vigilant and calm, 1: restless, 2: disturbed, 3: very disturbed and 4: controversy and fights). Method of measurement: pain is measured by face scale and children's agitation will measured by the Richmond Agitation Sedation Score.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Haghighatjooy

Zahedan University of Medical Sciences

m.haghighatjoo@zaums.ac.ir+98 54 3329 5715

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026