Drug therapy for improving the renal function after kidney transplantation

Investigating the effects of dexmedetomidine infusion during surgery on renal function parameters in patients receiving kidney transplantation

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017101331487N5

Enrollment

Registered

2017-10-24

Start date

2017-11-06

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

End-stage renal disease. Chronic kidney disease, stage 5

Interventions

Intervention 1: Control. Intervention 2: Dexmedetomidine infusion with dose of 1 mcg/kg/hour.

Placebo

Treatment - Drugs

Control

Dexmedetomidine infusion with dose of 1 mcg/kg/hour

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: - end stage renal disease (ESRD) patients - candidate for renal transplant - graft from living donor - age from 18 to 70 years old Exclusion criteria: - bradycardia (HR<50) - hypotension (SBP<100) - ejection fraction below 30% (EF<30%) - transplant from cadaver - simultaneous transplantation of kidney and pancreas - having contraindication for kidney transplantation

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Glomerular filtration rate. Timepoint: After patients transfer to ICU, then every one hours until 6 hours after transfer to ICU, then every two hours until 24 hours after ICU and then every 6 hours until the time of discharge. Method of measurement: Biochemistry analyzer.;Creatinine. Timepoint: After patients transfer to ICU, then every one hours until 6 hours after transfer to ICU, then every two hours until 24 hours after ICU and then every 6 hours until the time of discharge. Method of measurement: Biochemistry analyzer.;Urea. Timepoint: After patients transfer to ICU, then every one hours until 6 hours after transfer to ICU, then every two hours until 24 hours after ICU and then every 6 hours until the time of discharge. Method of measurement: Biochemistry analyzer.;Sodium. Timepoint: After patients transfer to ICU, then every one hours until 6 hours after transfer to ICU, then every two hours until 24 hours after ICU and then every 6 hours until the time of discharge. Method of measurement: Biochemistry analyzer.;Hemoglobin. Timepoint: After patients transfer to ICU, then every one hours until 6 hours after transfer to ICU, then every two hours until 24 hours after ICU and then every 6 hours until the time of discharge. Method of measurement: Hematology analyzer.;Hematocrit. Timepoint: After patients transfer to ICU, then every one hours until 6 hours after transfer to ICU, then every two hours until 24 hours after ICU and then every 6 hours until the time of discharge. Method of measurement: Hematology analyzer.	—

Measure

Time frame

Glomerular filtration rate. Timepoint: After patients transfer to ICU, then every one hours until 6 hours after transfer to ICU, then every two hours until 24 hours after ICU and then every 6 hours until the time of discharge. Method of measurement: Biochemistry analyzer.;Creatinine. Timepoint: After patients transfer to ICU, then every one hours until 6 hours after transfer to ICU, then every two hours until 24 hours after ICU and then every 6 hours until the time of discharge. Method of measurement: Biochemistry analyzer.;Urea. Timepoint: After patients transfer to ICU, then every one hours until 6 hours after transfer to ICU, then every two hours until 24 hours after ICU and then every 6 hours until the time of discharge. Method of measurement: Biochemistry analyzer.;Sodium. Timepoint: After patients transfer to ICU, then every one hours until 6 hours after transfer to ICU, then every two hours until 24 hours after ICU and then every 6 hours until the time of discharge. Method of measurement: Biochemistry analyzer.;Hemoglobin. Timepoint: After patients transfer to ICU, then every one hours until 6 hours after transfer to ICU, then every two hours until 24 hours after ICU and then every 6 hours until the time of discharge. Method of measurement: Hematology analyzer.;Hematocrit. Timepoint: After patients transfer to ICU, then every one hours until 6 hours after transfer to ICU, then every two hours until 24 hours after ICU and then every 6 hours until the time of discharge. Method of measurement: Hematology analyzer.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Mehrdad Mesbah Kiaee

Iran University of Medical Sciences

dr.mmesbah@gmail.com+98 21 8670 2503

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026