Comparing the effects of Atorvastatin and Rosuvastatin in preventing acute kidney injury due to contrast media

Comparison the effects of Atorvastatin and Rosuvastatin in preventing contrast induced nephropathy in myocarial infarction patients underwent primary per-cutaneous coronary intervention

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017101236737N1

Enrollment

200

Registered

2017-11-19

Start date

2016-08-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Contrast Induced Nephropathy. Other and unspecified drugs and medicament

Interventions

Intervention 1: oral atorvastatin 80mg before PPCI then 40mg bid after PPCI. Intervention 2: Rosuvastatin 40mg before PPCI then 20mg bid after PPCI.

Treatment - Drugs

oral atorvastatin 80mg before PPCI then 40mg bid after PPCI

Rosuvastatin 40mg before PPCI then 20mg bid after PPCI

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria: occurrence of first episode of ST elevation Myocardial Infarction (STEMI); performing primary per-cutaneous coronary intervention for patients. Exclusion criteria: patients under-dialysis; acute kidney injury before angiography; cardiogenic shock; consumption of drugs like N-acetyl cysteine, vitamin C, consumption of venous contrast for other cause, manitol, diuretics, Theophylline and Dopamin in recent two weeks before PCI; having intra-aortic balloon pump; patients with previous cardiac surgery; patients who were candidate for CABG after angioplasty; patients who received G2b3a drugs during PPCI

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Level of serum creatinine. Timepoint: 24 hours after intervention and 72 hours after intervention. Method of measurement: mg/ deciliter.	—

Secondary

Measure	Time frame
Glumerolar filtration rate. Timepoint: 24hours after intervention and 72hours after intervention. Method of measurement: ml/min/1.73 m2.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHasan Amirsoleimani

Mashhad University of Medical Sciences

amirsoleimanih921@mums.ac.ir+98 51 3840 0000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026