The effect of Vitamin D Supplementation on Cognitive Functions in Patients Receiving Maintenance Methadone Treatment

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017101133079N4

Enrollment

Registered

2017-10-12

Start date

2017-04-04

Completion date

Unknown

Last updated

2019-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Addiction. Mental and behavioural disorders due to psychoactive substance use

Interventions

Intervention 1: Intervention group: 50000 IU vitamin D (Zahravi, Tabriz, Iran), once every 2 weeks, for 24 weeks orally. Intervention 2: Intervention and control group: Methadone Maintenance Therapy (

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Patients that receiving methadone maintenance treatment Aged 18 to 60 years

Exclusion criteria

Exclusion criteria: Not living in Kashan Taking vitamin D, multivitamin-mineral, and antioxidant supplements during the last 3 months before the intervention.

Design outcomes

Primary

Measure	Time frame
Risky Decision Making. Timepoint: At the baseline and after intervention (24 weeks). Method of measurement: Iowa Gambling Task (IGT).;Memory. Timepoint: At the baseline and after intervention (24 weeks). Method of measurement: Wechsler Logic Memory.;Verba Fluency. Timepoint: At the baseline and after intervention (24 weeks). Method of measurement: FAS task.;Speed Processing. Timepoint: At the baseline and after intervention (24 weeks). Method of measurement: Digit Symbol and Trial Making Test (TMT).	—

Measure

Time frame

Risky Decision Making. Timepoint: At the baseline and after intervention (24 weeks). Method of measurement: Iowa Gambling Task (IGT).;Memory. Timepoint: At the baseline and after intervention (24 weeks). Method of measurement: Wechsler Logic Memory.;Verba Fluency. Timepoint: At the baseline and after intervention (24 weeks). Method of measurement: FAS task.;Speed Processing. Timepoint: At the baseline and after intervention (24 weeks). Method of measurement: Digit Symbol and Trial Making Test (TMT).

—

Secondary

Measure	Time frame
Depression. Timepoint: At the baseline and after intervention (24 weeks). Method of measurement: Beck Depression Inventory (BDI).;Anxiety. Timepoint: At the baseline and after intervention (24 weeks). Method of measurement: Beck Anxiety Inventory (BAI).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMorad Rasouli-Azad

Kashan University of Medical Science

mrasoliazad@yahoo.com+98 31 5554 0021

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026