Effect of supplementation in treatment of patients with gestational diabetes

The effect of probiotic supplementation on gene expression related to insulin, lipid and inflammation in patients with gestational diabetes

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20171010036697N1

Enrollment

Registered

2018-01-03

Start date

2017-10-02

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gestational diabetes. Diabetes mellitus in pregnancy, unspecified

Interventions

Intervention 1: Control group: placebo, daily, for 6 weeks orally. Intervention 2: Intervention group: Probiotic supplements containing four strains of Lactobacillus acidophilus (2×109 CFU/g), Lacto

Placebo

Treatment - Drugs

Control group: placebo, daily, for 6 weeks orally.

Intervention group: Probiotic supplements containing four strains of Lactobacillus acidophilus (2×109 CFU/g), Lactobacillus casei (2×109 CFU/g) and Bifidobacterium bifidum (2×109 CFU/g),Lactobacillu

Eligibility

Sex/Gender

Female

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: patients with gestational diabetes; aged 18 to 40 years old

Exclusion criteria

Exclusion criteria: Exclusion criterion: unwillingness to cooperate

Design outcomes

Primary

Measure	Time frame
Expressed levels of PPAR-? gene. Timepoint: At the beginning of the study and 6 weeks after intervention. Method of measurement: PCR.;Expressed levels of GLUT-1 gene. Timepoint: At the beginning of the study and 6 weeks after intervention. Method of measurement: PCR.	—

Secondary

Measure	Time frame
Expressed levels of TNF-a gene. Timepoint: At the beginning of the study and 6 weeks after intervention. Method of measurement: PCR.;Expressed levels of IL-8 gene. Timepoint: At the beginning of the study and 6 weeks after intervention. Method of measurement: PCR.;Expressed levels of IL-1 gene. Timepoint: At the beginning of the study and 6 weeks after intervention. Method of measurement: PCR.;Expressed levels LDLR gene. Timepoint: At the beginning of the study and 6 weeks after intervention. Method of measurement: PCR.;Expressed levels of LPa gene. Timepoint: At the beginning of the study and 6 weeks after intervention. Method of measurement: PCR.	—

Measure

Time frame

Expressed levels of TNF-a gene. Timepoint: At the beginning of the study and 6 weeks after intervention. Method of measurement: PCR.;Expressed levels of IL-8 gene. Timepoint: At the beginning of the study and 6 weeks after intervention. Method of measurement: PCR.;Expressed levels of IL-1 gene. Timepoint: At the beginning of the study and 6 weeks after intervention. Method of measurement: PCR.;Expressed levels LDLR gene. Timepoint: At the beginning of the study and 6 weeks after intervention. Method of measurement: PCR.;Expressed levels of LPa gene. Timepoint: At the beginning of the study and 6 weeks after intervention. Method of measurement: PCR.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZatollah Asemi

Kashan University of Medical Sciences

asemi_z@kaums.ac.ir+98 31 5546 3378

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026